Self-administered transcranial direct current stimulation for pain in older adults with knee osteoarthritis: A randomized controlled study.
Self-administered transcranial direct current stimulation for pain in older adults with knee osteoarthritis: A randomized controlled study.
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DOI：
10.1016/j.brs.2022.06.003
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发表时间：
2022-07
影响因子：
7.7
通讯作者：
Ahn, Hyochol
中科院分区：
文献类型：
--
作者：
Martorella, Geraldine;Mathis, Kenneth;Miao, Hongyu;Wang, Duo;Park, Lindsey;Ahn, Hyochol
膝关节骨关节炎（OA）是老年人疼痛的主要原因。先前的研究表明，基于临床的经颅直流电刺激（tDCS）可有效减轻各种人群的疼痛，但尚未发表的研究使用随机临床研究报告了基于家庭的自我给药tDCS在膝关节OA老年人中的疗效。本研究的目的是评价tDCS对膝关节OA疼痛成人患者临床疼痛强度的有效性和可行性。120名年龄50 - 85岁的膝关节OA疼痛参与者被随机分配接受15次每日2 mA tDCS治疗20 min（n = 60）或假tDCS治疗（n = 60），持续3周，并通过远程医疗进行远程监督。临床疼痛强度通过数字评定量表和西安大略和麦克马斯特大学骨关节炎指数进行测量。此外，我们通过问卷调查收集了tDCS经验的数据。参与者（68%为女性）的平均年龄为66岁。在完成15个每日疗程后，与假tDCS相比，活性tDCS显著降低了疼痛强度（Cohen d = 1.20; p值< 0.0001）。参与者对他们的tDCS体验表现出很高的满意度，并且没有不良事件。我们证明，在家中自我管理的tDCS是可行的，并减少临床疼痛强度的老年人与膝关节OA，这可以增加其可及性。未来的多中心随机对照试验研究需要验证我们的研究结果。ClinicalTrials.gov标识符NCT 04016272。
Knee osteoarthritis (OA) is a leading cause of pain in older adults. Previous studies indicated clinic-based transcranial direct current stimulation (tDCS) was effective to reduce pain in various populations, but no published studies have reported the efficacy of home-based self-administered tDCS in older adults with knee OA using a randomized clinical study. The purpose of this study was to evaluate the efficacy and feasibility of tDCS on clinical pain intensity in adults with knee OA pain. One hundred twenty participants aged 50e85 years with knee OA pain were randomly assigned to receive fifteen daily sessions of 2 mA tDCS for 20 min (n = 60) or sham tDCS (n = 60) over 3 weeks with remote supervision via telehealth. Clinical pain intensity was measured by the Numeric Rating Scale and Western Ontario and McMaster Universities Osteoarthritis Index. Also, we collected data on the tDCS experience via a questionnaire. Participants (68% female) had a mean age of 66 years. Active tDCS significantly reduced pain intensity compared to sham tDCS after completion of the fifteen daily sessions (Cohen’s d = 1.20; p-value < 0.0001). Participants showed high levels of satisfaction with their tDCS experience, and there have been no adverse events. We demonstrated that home-based self-administered tDCS was feasible and reduced clinical pain intensity in older adults with knee OA, which can increase its accessibility. Future studies with multi-site randomized controlled trials are needed to validate our findings. ClinicalTrials.gov Identifier NCT04016272.
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影响因子：
3
作者：
Charvet LE;Kasschau M;Datta A;Knotkova H;Stevens MC;Alonzo A;Loo C;Krull KR;Bikson M
通讯作者：
Bikson M
DOI：
10.1007/s12160-016-9844-2
发表时间：
2017-04
期刊：
Annals of behavioral medicine : a publication of the Society of Behavioral Medicine
影响因子：
--
作者：
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通讯作者：
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影响因子：
7.7
作者：
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通讯作者：
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影响因子：
4
作者：
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通讯作者：
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影响因子：
4
作者：
Brietzke, Aline P.;Zortea, Maxciel;Caumo, Wolnei
通讯作者：
Caumo, Wolnei