Glucocorticoid ultradian rhythmicity differentially regulates mood and resting state networks in the human brain: A randomised controlled clinical trial.
Glucocorticoid ultradian rhythmicity differentially regulates mood and resting state networks in the human brain: A randomised controlled clinical trial.
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DOI：
10.1016/j.psyneuen.2020.105096
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发表时间：
2021-03
影响因子：
3.7
通讯作者：
Lightman SL
中科院分区：
文献类型：
--
作者：
Kalafatakis K;Russell GM;Ferguson SG;Grabski M;Harmer CJ;Munafò MR;Marchant N;Wilson A;Brooks JC;Thakrar J;Murphy P;Thai NJ;Lightman SL
肾上腺糖皮质激素分泌进入体循环的特征在于复杂的节律，由昼夜变化组成，由短持续时间激素脉冲的潜在超日节律的脉冲幅度变化形成。为了阐明糖皮质激素脉动性在人类中的潜在神经生物学意义，我们对15名健康志愿者进行了一项随机、双盲、安慰剂对照、三向交叉的临床试验，通过招募功能性神经成像、计算机化行为测试和生态瞬时评估，研究了不同糖皮质激素节律对静息状态下情绪和神经活动测量的影响。内源性糖皮质激素的生物合成被抑制，皮质类固醇的血浆水平恢复氢化可的松替代在三个不同的制度，无论是模仿正常的超昼夜和昼夜节律的激素，或保留正常的昼夜节律，但取消超昼夜节律的激素，或通过我们目前最好的口服替代方案，这导致在一个次优的昼夜和超昼夜节律。我们的研究结果表明，糖皮质激素替代的时间模式的变化影响（i）早晨自我感知活力，疲劳和注意力的水平，（ii）情绪变化的昼夜模式，（iii）人脑各种大规模静息状态网络的网络内功能连接，（iv）默认模式的功能连接，显着性和执行控制网络与皮质边缘系统的糖皮质激素敏感节点，以及（v）情绪变化和潜在的神经网络之间的功能关系。研究结果表明，超昼夜糖皮质激素节律的模式可以影响认知心理生理在非压力条件下，并打开了新的途径，我们的理解皮质醇脉动的神经心理学影响的目标，优化糖皮质激素替代策略。糖皮质激素节律的变化影响早晨的活力、疲劳和注意力。它们影响情绪的昼夜变化。它们调节人脑大规模静息状态网络的神经动力学。它们可以改变情绪变化和潜在神经网络之间的功能关系。
Adrenal glucocorticoid secretion into the systematic circulation is characterised by a complex rhythm, composed of the diurnal variation, formed by changes in pulse amplitude of an underlying ultradian rhythm of short duration hormonal pulses. To elucidate the potential neurobiological significance of glucocorticoid pulsatility in man, we have conducted a randomised, double-blind, placebo-controlled, three-way crossover clinical trial on 15 healthy volunteers, investigating the impact of different glucocorticoid rhythms on measures of mood and neural activity under resting conditions by recruiting functional neuroimaging, computerised behavioural tests and ecological momentary assessments. Endogenous glucocorticoid biosynthesis was pharmacologically suppressed, and plasma levels of corticosteroid restored by hydrocortisone replacement in three different regimes, either mimicking the normal ultradian and circadian profile of the hormone, or retaining the normal circadian but abolishing the ultradian rhythm of the hormone, or by our current best oral replacement regime which results in a suboptimal circadian and ultradian rhythm. Our results indicate that changes in the temporal mode of glucocorticoid replacement impact (i) the morning levels of self-perceived vigour, fatigue and concentration, (ii) the diurnal pattern of mood variation, (iii) the within-network functional connectivity of various large-scale resting state networks of the human brain, (iv) the functional connectivity of the default-mode, salience and executive control networks with glucocorticoid-sensitive nodes of the corticolimbic system, and (v) the functional relationship between mood variation and underlying neural networks. The findings indicate that the pattern of the ultradian glucocorticoid rhythm could affect cognitive psychophysiology under non-stressful conditions and opens new pathways for our understanding on the neuropsychological effects of cortisol pulsatility with relevance to the goal of optimising glucocorticoid replacement strategies. Changes in the glucocorticoid rhythm impact morning levels of vigour, fatigue and concentration. They affect the diurnal variation of mood. They modulate the neural dynamics of large-scale resting state networks of the human brain. They could alter the functional relationship between mood variation and underlying neural networks.
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影响因子：
--
作者：
Dzogang, Fabon;Lightman, Stafford;Cristianini, Nello
通讯作者：
Cristianini, Nello
DOI：
10.1080/10253890.2020.1806226
发表时间：
2021-03
期刊：
Stress (Amsterdam, Netherlands)
影响因子：
--
作者：
Huzard D;Rappeneau V;Meijer OC;Touma C;Arango-Lievano M;Garabedian MJ;Jeanneteau F
通讯作者：
Jeanneteau F
影响因子：
5.8
作者：
Gagliardi, Lucia;Nenke, Marni A.;Torpy, David J.
通讯作者：
Torpy, David J.
影响因子：
6.9
作者：
FOLSTEIN, MF;LURIA, R
通讯作者：
LURIA, R
影响因子：
3.7
作者：
Henckens, Marloes J. A. G.;van Wingen, Guido A.;Fernandez, Guillen
通讯作者：
Fernandez, Guillen