Experience and activity-dependent control of glucocorticoid receptors during the stress response in large-scale brain networks.
Experience and activity-dependent control of glucocorticoid receptors during the stress response in large-scale brain networks.
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大规模脑网络应激反应中糖皮质激素受体的经验和活动依赖性控制。
DOI：
10.1080/10253890.2020.1806226
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发表时间：
2021-03
期刊：
影响因子：
--
通讯作者：
Jeanneteau F
中科院分区：
文献类型：
--
作者：
Huzard D;Rappeneau V;Meijer OC;Touma C;Arango-Lievano M;Garabedian MJ;Jeanneteau F
糖皮质激素应激激素在个体之间以及器官、组织和细胞内的作用的多样性受年龄、性别、遗传、代谢和暴露量的影响。然而，这些因素不能解释相同谱系或相似组织环境或同一个体的脑细胞中反应的异质性。在这里，我们认为，压力反应是不断更新的同步神经活动的大规模大脑网络。这通过活性依赖性和糖皮质激素信号传导途径之间的串扰通信在分子、细胞和行为水平上发生，其更新了基于先前经验的反应的多样性。这种贝叶斯过程决定了对身体和外部世界需求的适应。我们提出了一个框架，以了解糖皮质激素在整个大脑网络中的作用的多样性对于支持最佳健康是至关重要的，而它的破坏可能有助于与压力相关的疾病，如重度抑郁症的病理生理学，以及对治疗性治疗的抵抗。
The diversity of actions of the glucocorticoid stress hormones among individuals and within organs, tissues and cells is shaped by age, gender, genetics, metabolism, and the quantity of exposure. However, such factors cannot explain the heterogeneity of responses in the brain within cells of the same lineage, or similar tissue environment, or in the same individual. Here, we argue that the stress response is continuously updated by synchronized neural activity on large-scale brain networks. This occurs at the molecular, cellular and behavioral levels by crosstalk communication between activity-dependent and glucocorticoid signaling pathways, which updates the diversity of responses based on prior experience. Such a Bayesian process determines adaptation to the demands of the body and external world. We propose a framework for understanding how the diversity of glucocorticoid actions throughout brain networks is essential for supporting optimal health, while its disruption may contribute to the pathophysiology of stress-related disorders, such as major depression, and resistance to therapeutic treatments.
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与压力有关的精神疾病的性别差异：神经生物学观点。
影响因子：
7.4
作者：
Bangasser, Debra A.;Valentino, Rita J.
通讯作者：
Valentino, Rita J.
DOI：
10.1038/nrm3072
发表时间：
2011-03
期刊：
Nature reviews. Molecular cell biology
影响因子：
--
作者：
通讯作者：
--
影响因子：
64.5
作者：
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通讯作者：
Xu, HE
DOI：
10.1007/978-1-4939-2895-8_2
发表时间：
2015-01-01
期刊：
GLUCOCORTICOID SIGNALING: FROM MOLECULES TO MICE TO MAN
影响因子：
--
作者：
Arango-Lievano, Margarita;Lambert, W. Marcus;Jeanneteau, Freddy
通讯作者：
Jeanneteau, Freddy
影响因子：
30.8
作者：
Binder, EB;Salyakina, D;Muller-Myhsok, B
通讯作者：
Muller-Myhsok, B