Polarity-specific effects of motor transcranial direct current stimulation on fMRI resting state networks.
Polarity-specific effects of motor transcranial direct current stimulation on fMRI resting state networks.
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DOI：
10.1016/j.neuroimage.2013.11.037
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发表时间：
2014-03
期刊：
影响因子：
5.7
通讯作者：
Stagg CJ
中科院分区：
文献类型：
--
作者：
Amadi U;Ilie A;Johansen-Berg H;Stagg CJ
经颅直流电刺激 (tDCS) 已被用于改善健康人群和患者人群的运动表现。然而，我们对支持这种行为效应的大规模神经塑性变化的理解是有限的。在这里，我们使用基于种子的方法和独立成分分析 (ICA) 方法来探测 tDCS 引起的静息状态活动的改变，目的是确定应用于初级运动皮层 (M1) 的 tDCS 对大脑内运动和非运动网络的影响。受试者参加了三个单独的课程，在此期间，在 1 mA 阳极、阴极或假 tDCS 之前和之后 10 分钟获取静息 fMRI 扫描。阴极 tDCS 增加了左右辅助运动区 (SMA) 以及 M1 左右手区域之间静息 fMRI 信号的半球间一致性。前运动皮层 (PMC) 也有类似的趋势。在 ICA 生成的运动和默认模式网络中，阴极 tDCS 后的功能连接性明显增加。此外，默认模式网络的整体强度也得到了增强。阳极和假 tDCS 均未对静息状态连接产生显着变化。这项工作表明，M1 的阴极 tDCS 会影响静止时的运动网络。此外，阴极 tDCS 对默认模式网络的影响支持这样的假设：自上而下控制的减弱可能导致阴极 tDCS 引起的运动性能受损。静息态 BOLD fMRI 数据是在 tDCS 应用于 M1 之前和之后获得的。阴极 tDCS 增加了 M1 手部区域之间的半球间相关性。阴极 tDCS 增强了 ICA 生成的电机和默认网络的连接性。阴极 tDCS 提高了默认网络的整体强度。
Transcranial direct current stimulation (tDCS) has been used to modify motor performance in healthy and patient populations. However, our understanding of the large-scale neuroplastic changes that support such behavioural effects is limited. Here, we used both seed-based and independent component analyses (ICA) approaches to probe tDCS-induced modifications in resting state activity with the aim of establishing the effects of tDCS applied to the primary motor cortex (M1) on both motor and non-motor networks within the brain. Subjects participated in three separate sessions, during which resting fMRI scans were acquired before and after 10 min of 1 mA anodal, cathodal, or sham tDCS. Cathodal tDCS increased the inter-hemispheric coherence of resting fMRI signal between the left and right supplementary motor area (SMA), and between the left and right hand areas of M1. A similar trend was documented for the premotor cortex (PMC). Increased functional connectivity following cathodal tDCS was apparent within the ICA-generated motor and default mode networks. Additionally, the overall strength of the default mode network was increased. Neither anodal nor sham tDCS produced significant changes in resting state connectivity. This work indicates that cathodal tDCS to M1 affects the motor network at rest. In addition, the effects of cathodal tDCS on the default mode network support the hypothesis that diminished top-down control may contribute to the impaired motor performance induced by cathodal tDCS. Resting state BOLD fMRI data was acquired before and after tDCS applied to M1. Cathodal tDCS increased inter-hemispheric correlations between the M1 hand areas. Cathodal tDCS increased connectivity in ICA-generated motor and default networks. Cathodal tDCS increased the overall strength of the default network.
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10.1098/rstb.2005.1634
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