Reorganizing the intrinsic functional architecture of the human primary motor cortex during rest with non-invasive cortical stimulation.
Reorganizing the intrinsic functional architecture of the human primary motor cortex during rest with non-invasive cortical stimulation.
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DOI：
10.1371/journal.pone.0030971
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Nitsche MA
中科院分区：
文献类型：
--
作者：
Polanía R;Paulus W;Nitsche MA
初级运动皮质(M1)是参与自主运动产生的主要效应器结构，直接参与运动学习。M1的固有水平神经元连接具有短期和长期可塑性，这是学习相关地图重组的强大底物。经颅直流电刺激(TDC)在M1上施加几分钟已被证明可以诱导相对持久的可塑性改变，并调节运动性能。在这里，我们检验了这样一种假设，即tDCS对M1诱导的相对持久的突触修饰导致M1神经元群体之间的联系改变，这可能反映在其功能结构的变化上。在休息期间，在tDCS10分钟之前和之后立即采集fMRI静息状态数据集，将阳极/阴极放置在左侧M1上。对于每个功能数据集，标记属于Brodmann Area 4(BA4)的灰质体素，然后计算基于BA4体素的同步矩阵，并对其进行阈值处理以构建无向图。计算表征功能网络结构的节点网络参数(连通度、聚类系数和特征路径长度)，并将其转换为体积图，并在刺激前后进行比较。在背外侧-BA4区，阴极tDCs促进局部连接，而阳极-tDCs增强M1内的远距离功能交流。此外，M1的功能结构在基线时越有效，tDCs诱导的功能调节就越有效。总而言之，我们在这里展示了非侵入性地重组M1的内在功能体系结构并想象这样的改变是可能的。
The primary motor cortex (M1) is the main effector structure implicated in the generation of voluntary movements and is directly involved in motor learning. The intrinsic horizontal neuronal connections of M1 exhibit short-term and long-term plasticity, which is a strong substrate for learning-related map reorganization. Transcranial direct current stimulation (tDCS) applied for few minutes over M1 has been shown to induce relatively long-lasting plastic alterations and to modulate motor performance. Here we test the hypothesis that the relatively long-lasting synaptic modification induced by tDCS over M1 results in the alteration of associations among populations of M1 neurons which may be reflected in changes of its functional architecture. fMRI resting-state datasets were acquired immediately before and after 10 minutes of tDCS during rest, with the anode/cathode placed over the left M1. For each functional dataset, grey-matter voxels belonging to Brodmann area 4 (BA4) were labelled and afterwards BA4 voxel-based synchronization matrices were calculated and thresholded to construct undirected graphs. Nodal network parameters which characterize the architecture of functional networks (connectivity degree, clustering coefficient and characteristic path-length) were computed, transformed to volume maps and compared before and after stimulation. At the dorsolateral-BA4 region cathodal tDCS boosted local connectedness, while anodal-tDCS enhanced long distance functional communication within M1. Additionally, the more efficient the functional architecture of M1 was at baseline, the more efficient the tDCS-induced functional modulations were. In summary, we show here that it is possible to non-invasively reorganize the intrinsic functional architecture of M1, and to image such alterations.
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影响因子：
1.7
作者：
Fregni, F;Boggio, PS;Pascual-Leone, A
通讯作者：
Pascual-Leone, A
影响因子：
5.5
作者：
Cirillo, John;Lavender, Andrew P.;Semmler, John G.
通讯作者：
Semmler, John G.
影响因子：
5.3
作者：
Achard, S;Salvador, R;Bullmore, ET
通讯作者：
Bullmore, ET
DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
影响因子：
5.7
作者：
Jenkinson, M;Bannister, P;Smith, S
通讯作者：
Smith, S