Cholesterol, the central lipid of mammalian cells.
Cholesterol, the central lipid of mammalian cells.
复制标题
DOI：
10.1016/j.ceb.2010.05.004
复制
发表时间：
2010-08
影响因子：
7.5
通讯作者：
van Meer G
中科院分区：
文献类型：
--
作者：
Maxfield FR;van Meer G
尽管它对哺乳动物细胞生物学和人类健康很重要，但胆固醇稳态的许多基本方面还没有被很好地了解。最近发现了一种新的调节机制，涉及一种名为PCSK9的血清蛋白，它可以深刻地影响脂蛋白及其受体，甚至对于胆固醇通过脂蛋白传递到细胞也是如此。细胞可以通过需要ABC转运蛋白活性的过程来输出胆固醇，但胆固醇运输的分子机制仍不清楚。不同细胞器中的胆固醇水平相差5-10倍，维持这些差异的机制现在已部分了解。已有几种蛋白质被提出在胆固醇的细胞器间运动中发挥作用，但调节胆固醇在细胞内的运输和分布的许多方面的机制仍有待研究。内质网是负责调节胆固醇合成的主要细胞器，仔细的测量表明，负责胆固醇感应的蛋白质在非常窄的胆固醇浓度范围内做出反应，对胆固醇合成提供非常精确的开关控制。
Despite its importance for mammalian cell biology and human health, there are many basic aspects of cholesterol homeostasis that are not well understood. Even for the well-characterized delivery of cholesterol to cells via lipoproteins, a novel regulatory mechanism has been discovered recently, involving a serum protein called PCSK9, which profoundly affects lipoproteins and their receptors. Cells can export cholesterol by processes that require the activity of ABC transporters, but the molecular mechanisms for cholesterol transport remain unclear. Cholesterol levels in different organelles vary by 5–10 fold, and the mechanisms for maintaining these differences are now partially understood. Several proteins have been proposed to play a role in the inter-organelle movement of cholesterol, but many aspects of the mechanisms for regulating intracellular transport and distribution of cholesterol remain to be worked out. The endoplasmic reticulum is the main organelle responsible for regulation of cholesterol synthesis, and careful measurements have shown that the proteins responsible for sterol sensing respond over a very narrow range of cholesterol concentrations to provide very precise, switch-like control over cholesterol synthesis.
登录
查看更多内容
DOI：
10.1083/jcb.200901145
发表时间：
2009-05-18
期刊：
The Journal of cell biology
影响因子：
--
作者：
Klemm RW;Ejsing CS;Surma MA;Kaiser HJ;Gerl MJ;Sampaio JL;de Robillard Q;Ferguson C;Proszynski TJ;Shevchenko A;Simons K
通讯作者：
Simons K
DOI：
10.1073/pnas.0907354106
发表时间：
2009-12-29
影响因子：
11.1
作者：
Kamal, Marzuk M.;Mills, Deryck;Howard, Jonathon
通讯作者：
Howard, Jonathon
影响因子：
4.8
作者：
Infante, Rodney E.;Abi-Mosleh, Lina;Goldstein, Joseph L.
通讯作者：
Goldstein, Joseph L.
DOI：
10.1161/atvbaha.108.173344
发表时间：
2008-10
期刊：
Arteriosclerosis, thrombosis, and vascular biology
影响因子：
--
作者：
Devlin CM;Leventhal AR;Kuriakose G;Schuchman EH;Williams KJ;Tabas I
通讯作者：
Tabas I
影响因子：
4.8
作者：
Bottomley, Matthew J.;Cirillo, Agostino;Carfi, Andrea
通讯作者：
Carfi, Andrea