Fatty acid amide hydrolase binding is inversely correlated with amygdalar functional connectivity: a combined positron emission tomography and magnetic resonance imaging study in healthy individuals.
Fatty acid amide hydrolase binding is inversely correlated with amygdalar functional connectivity: a combined positron emission tomography and magnetic resonance imaging study in healthy individuals.
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DOI：
10.1503/jpn.200010
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发表时间：
2021-03-17
期刊：
影响因子：
--
通讯作者：
Boileau I
中科院分区：
文献类型：
--
作者：
Green DGJ;Kim J;Kish SJ;Tyndale RF;Hill MN;Strafella AP;Tong J;McCluskey T;Westwood DJ;Houle S;Lobaugh NJ;Boileau I
内源性大麻素酶脂肪酸酰胺水解酶（FAAH）的上调与额杏仁回路的异常活动有关，额杏仁回路是创伤后应激障碍的一个标志。我们测试了这样的假设：杏仁核中的 FAAH 水平与杏仁核和前额皮质之间的功能连接呈负相关，有助于压力和情感控制。 31 名健康参与者使用 FAAH 探针 [C-11]CURB 完成了正电子发射断层扫描 (PET) 成像，以及静息态功能 MRI 扫描。对参与者进行了 FAAH 多态性 rs324420 的基因分型，并对特质神经质进行了评估。我们使用预先确定的感兴趣区域（包括膝下腹内侧前额叶皮层 [sgvmPFC] 和背侧前扣带皮层 [dACC]）和种子到体素方法计算杏仁核功能连接。我们对功能连接进行了相关分析，以杏仁核 [C-11]CURB 结合作为感兴趣的变量。杏仁核与 sgvmPFC 和 dACC 的功能连接强度与杏仁核中的 [C-11]CURB 结合呈负相关（sgvmPFC：r = -0.38，q = 0.04；dACC：r = -0.44；q = 0.03）。使用种子到体素方法部分复制了研究结果，该方法显示腹内侧前额叶皮层中存在一个簇，包括 dACC 中的体素，但不包括 sgvmPFC（簇级、家庭错误率校正 p < 0.05）。我们没有复制 FAAH 多态性 (rs324420) 和杏仁核功能连接之间关系的早期发现。我们的数据提供了初步证据，表明杏仁核中较低水平的 FAAH 与额杏仁核功能耦合的增加有关。我们的研究结果与 FAAH 在调节人类恐惧和情绪处理的大脑回路中的作用一致。
Upregulation of the endocannabinoid enzyme fatty acid amide hydrolase (FAAH) has been linked to abnormal activity in frontoamygdalar circuits, a hallmark of posttraumatic stress disorder. We tested the hypothesis that FAAH levels in the amygdala were negatively correlated with functional connectivity between the amygdala and prefrontal cortex, subserving stress and affect control. Thirty-one healthy participants completed positron emission tomography (PET) imaging with the FAAH probe [C-11]CURB, and resting-state functional MRI scans. Participants were genotyped for the FAAH polymorphism rs324420, and trait neuroticism was assessed. We calculated amygdala functional connectivity using pre-determined regions of interest (including the subgenual ventromedial prefrontal cortex [sgvmPFC] and the dorsal anterior cingulate cortex [dACC]) and a seed-to-voxel approach. We conducted correlation analyses on functional connectivity, with amygdala [C-11]CURB binding as a variable of interest. The strength of amygdala functional connectivity with the sgvmPFC and dACC was negatively correlated with [C-11]CURB binding in the amygdala (sgvmPFC: r = −0.38, q = 0.04; dACC: r = −0.44; q = 0.03). Findings were partly replicated using the seed-to-voxel approach, which showed a cluster in the ventromedial prefrontal cortex, including voxels in the dACC but not the sgvmPFC (cluster-level, family-wise error rate corrected p < 0.05). We did not replicate earlier findings of a relationship between an FAAH polymorphism (rs324420) and amygdala functional connectivity. Our data provide preliminary evidence that lower levels of FAAH in the amygdala relate to increased frontoamygdalar functional coupling. Our findings were consistent with the role of FAAH in regulating brain circuits that underlie fear and emotion processing in humans.
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