Circadian rhythm of erythropoietin in human serum
Circadian rhythm of erythropoietin in human serum
复制标题
人血清中促红细胞生成素的昼夜节律
DOI：
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发表时间：
1989
影响因子：
6.5
通讯作者：
G. Birgegarrd
中科院分区：
文献类型：
--
作者：
L. Wide;C. Bengtsson And;G. Birgegarrd
摘要当使用标记的重组hEpo和尿hEpo抗血清对血清中促红细胞生成素（S-Epo）的灵敏放射免疫测定法进行临床应用评价时，在24小时内观察到较大的个体内变异。在27例住院成人患者中研究了昼夜节律在白天变化的可能性，这在临床评价S-Epo水平时必须考虑。他们患有各种疾病，但所有人在08.00或12.00小时的S-Epo水平都在健康个体的参考范围内，并且在24小时内皮质醇水平正常。发现S-Epo具有明显的昼夜节律，08.00时平均水平最低，16.00时增加42%，20.00时增加60%至最高。在08.00或12.00时S-Epo水平在参考范围（3.3-13.5 IU/l）内的27例患者中，12例（44%）在16.00时水平高于该范围。对于S-Epo水平的临床评价，必须考虑血液标本采集的时间。建议在早晨07.30至12.00之间采集血液样本。观察到的S-Epo昼夜节律背后的机制尚不清楚。
Summary. When a sensitive radioimmunoassay for erythropoietin in serum (S‐Epo), using labelled recombinant hEpo and antiserum to urinary hEpo, was evaluated for clinical use, a large intra‐individual variation was observed during a 24 h period. The possibility of a circadian rhythm with a variation during day time which has to be considered for clinical evaluation of the S‐Epo level was investigated in 27 hospitalized adult patients. They had various illnesses, but all had a level of S‐Epo at 08.00 or 12.00 hours within the reference range of healthy individuals and normal cortisol levels during the 24 h. A well‐marked circadian rhythm of S‐Epo was found with the lowest mean level at 08.00 hours, a 42% increase at 16.00 hours and a 60% increase to the highest at 20.00 hours. Twelve (44%) of the 27 patients, with S‐Epo levels within the reference range (3.3–13.5 IU/l) at 08.00 or 12.00 hours, had levels above this range at 16.00 hours. For clinical evaluation of the S‐Epo level, the time of day for collection of the blood specimen has to be taken into consideration. It is recommended that blood specimens are taken in the morning between 07.30 and 12.00 hours. The mechanisms behind the observed circadian rhythm of S‐Epo are unknown.
促红细胞生成素的放射免疫测定：正常人体和造血障碍患者的血清水平。
DOI：
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发表时间：
1982
期刊：
The Journal of laboratory and clinical medicine
影响因子：
--
作者：
Rege,AB;Brookins,J;Fisher,JW
通讯作者：
Fisher,JW
DOI：
10.1073/pnas.82.22.7580
发表时间：
1985-01-01
影响因子：
11.1
作者：
LIN, FK;SUGGS, S;GOLDWASSER, E
通讯作者：
GOLDWASSER, E