Myocardial T1 mapping and extracellular volume quantification: an overview of technical and biological confounders.
Myocardial T1 mapping and extracellular volume quantification: an overview of technical and biological confounders.
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DOI：
10.1007/s10554-017-1235-7
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发表时间：
2018-01
期刊：
影响因子：
--
通讯作者：
Jerosch-Herold M
中科院分区：
文献类型：
--
作者：
Piechnik SK;Jerosch-Herold M
基于自旋-晶格弛豫时间T1（磁共振物理学理论中的基本性质）的新型组织生物标志物已成为心肌组织表征的新方法，具有许多经验证的临床应用。这篇文章的目的是作为一个概述的物理和生理机制的解释和任何实际测量T1的准确性，或衍生的生物标志物，如血管外容积分数，也包括潜在的陷阱的讨论。与基于T1的生物标志物的精确解释相关的许多警告和知识差距仍然存在，这些问题正在通过正在进行的研究逐步解决。同样重要的是，进一步仔细的标准化将为这些新的基于T1的组织重塑生物标志物的更广泛的临床翻译铺平道路，这些生物标志物已经被很好地验证了它们对病理生理变化的敏感性，尽管大部分是在单中心研究中。
Novel tissue biomarkers based on the spin–lattice relaxation time T1, a fundamental property in the theory of magnetic resonance physics, have emerged as a new approach for myocardial tissue characterization with many validated clinical applications. This article is intended as an overview of the physical and physiological mechanisms underlying the interpretation and the accuracy of any practical measurement of T1, or derived biomarkers such as extravascular volume fraction, and also includes a discussion of potential pitfalls. Numerous caveats und knowledge gaps related to the precise interpretation of T1-based biomarkers remain, which are being addressed incrementally through ongoing research. Equally important, further careful standardization will pave the way for a wider clinical translation of these novel T1-based biomarkers of tissue remodeling, which have been well validated for their sensitivity to pathophysiological changes, though for the most part in single-center studies.
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影响因子：
3.3
作者：
Goldfarb, JW;Arnold, S;Reichek, N
通讯作者：
Reichek, N
影响因子：
3.3
作者：
Gai, Neville D.;Stehning, Christian;Bluemke, David A.
通讯作者：
Bluemke, David A.
影响因子：
6.4
作者：
Chow, Kelvin;Kellman, Peter;Thompson, Richard B.
通讯作者：
Thompson, Richard B.
对比后T1映射的剂量校正心脏：MESA研究。
DOI：
10.1007/s10554-015-0754-3
发表时间：
2016-02
期刊：
The international journal of cardiovascular imaging
影响因子：
--
作者：
Gai ND;Sandfort V;Liu S;Lima JAC;Bluemke DA
通讯作者：
Bluemke DA
DOI：
10.1161/circimaging.112.979815
发表时间：
2013-01-01
期刊：
Circulation. Cardiovascular imaging
影响因子：
--
作者：
Coelho-Filho OR;Mongeon FP;Mitchell R;Moreno H Jr;Nadruz W Jr;Kwong R;Jerosch-Herold M
通讯作者：
Jerosch-Herold M