BCG-induced trained immunity in NK cells: Role for non-specific protection to infection.
BCG-induced trained immunity in NK cells: Role for non-specific protection to infection.
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DOI：
10.1016/j.clim.2014.10.005
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发表时间：
2014-12
期刊：
影响因子：
--
通讯作者：
Netea MG
中科院分区：
文献类型：
--
作者：
Kleinnijenhuis J;Quintin J;Preijers F;Joosten LA;Jacobs C;Xavier RJ;van der Meer JW;van Crevel R;Netea MG
先天免疫的适应性特征，也被称为“训练免疫”，最近已被证明是卡介苗接种的健康志愿者的单核细胞的特征。训练的免疫力通过单核细胞的表观遗传重编程导致响应于非相关病原体的细胞因子产生增加。最近，在病毒感染期间也在NK细胞中观察到记忆样特性，但不知道NK细胞的记忆特性是否有助于由于BCG疫苗接种而训练的免疫力。在这里，我们表明，卡介苗接种诱导NK细胞的促炎细胞因子的生产显着增加，以应对分枝杆菌和不相关的病原体在健康志愿者。此外，在播散性念珠菌病的小鼠模型中，BCG疫苗接种导致SCID小鼠的存活率增加，这部分依赖于NK细胞。因此，BCG疫苗接种诱导NK细胞对非相关微生物刺激的反应性增加。这些效应可能有助于BCG疫苗接种的非特异性（异源）有益效应。
Adaptive features of innate immunity, also termed ‘trained immunity’, have recently been shown to characterize monocytes of BCG vaccinated healthy volunteers. Trained immunity leads to increased cytokine production in response to non-related pathogens via epigenetic reprogramming of monocytes. Recently, memory-like properties were also observed in NK cells during viral infections, but nothing is know whether memory properties of NK cells contribute to trained immunity due to BCG vaccination. Here we show that BCG vaccination induced a significant increase in proinflammatory cytokine production by NK cells in response to both mycobacteria and unrelated pathogens in healthy volunteers. In addition, in a murine model of disseminated candidiasis, BCG vaccination led to an increased survival in SCID mice, which was partially dependent on NK cells. So, BCG vaccination induces an increased responsiveness of NK cells to non-related microbial stimuli. These effects may contribute to the non-specific (heterologous) beneficial effects of BCG vaccination.
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影响因子：
7.3
作者：
Cichocki F;Miller JS;Anderson SK;Bryceson YT
通讯作者：
Bryceson YT
影响因子：
30.3
作者：
Quintin J;Saeed S;Martens JHA;Giamarellos-Bourboulis EJ;Ifrim DC;Logie C;Jacobs L;Jansen T;Kullberg BJ;Wijmenga C;Joosten LAB;Xavier RJ;van der Meer JWM;Stunnenberg HG;Netea MG
通讯作者：
Netea MG
影响因子：
4.4
作者：
Marcenaro, Emanuela;Ferranti, Bruna;Moretta, Alessandro
通讯作者：
Moretta, Alessandro
影响因子：
64.8
作者：
Sun, Joseph C.;Beilke, Joshua N.;Lanier, Lewis L.
通讯作者：
Lanier, Lewis L.
影响因子：
3.7
作者：
Portevin D;Young D
通讯作者：
Young D