Candida albicans infection affords protection against reinfection via functional reprogramming of monocytes.
Candida albicans infection affords protection against reinfection via functional reprogramming of monocytes.
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DOI：
10.1016/j.chom.2012.06.006
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发表时间：
2012-08-16
影响因子：
30.3
通讯作者：
Netea MG
中科院分区：
文献类型：
--
作者：
Quintin J;Saeed S;Martens JHA;Giamarellos-Bourboulis EJ;Ifrim DC;Logie C;Jacobs L;Jansen T;Kullberg BJ;Wijmenga C;Joosten LAB;Xavier RJ;van der Meer JWM;Stunnenberg HG;Netea MG
脊椎动物的免疫记忆通常完全归因于T和B细胞的功能。最近有人提出，初始感染暴露后增强和持续的先天免疫应答也可能提供针对再感染的保护。通过测试“训练免疫力”的概念，我们发现缺乏功能性T和B淋巴细胞的小鼠可以以单核细胞依赖性的方式免受白色念珠菌的再次感染。C.白色念珠菌和真菌细胞壁β-葡聚糖诱导单核细胞的功能性重编程，导致体内和体外细胞因子产生增强。训练需要β-葡聚糖受体dectin-1和非经典Raf-1途径。β-葡聚糖对单核细胞的训练与H3 K4组蛋白三甲基化的稳定变化相关，这表明该现象涉及表观遗传机制。单核细胞的功能重编程，让人想起类似的NK细胞特性，支持“训练免疫”的概念，并可用于设计改进的疫苗接种策略。
Immunological memory in vertebrates is often exclusively attributed to T and B cell function. Recently it was proposed that the enhanced and sustained innate immune responses following initial infectious exposure may also afford protection against reinfection. Testing this concept of “trained immunity,” we show that mice lacking functional T and B lymphocytes are protected against reinfection with Candida albicans in a monocyte-dependent manner. C. albicans and fungal cell wall β-glucans induced functional reprogramming of monocytes, leading to enhanced cytokine production in vivo and in vitro. The training required the β-glucan receptor dectin-1 and the noncanonical Raf-1 pathway. Monocyte training by β-glucans was associated with stable changes in histone trimethylation at H3K4, which suggests the involvement of epigenetic mechanisms in this phenomenon. The functional reprogramming of monocytes, reminiscent of similar NK cell properties, supports the concept of “trained immunity” and may be employed for the design of improved vaccination strategies.
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影响因子：
30.5
作者：
Gringhuis, Sonja I.;den Dunnen, Jeroen;Geijtenbeek, Teunis B. H.
通讯作者：
Geijtenbeek, Teunis B. H.
影响因子：
64.8
作者：
Foster, Simmie L.;Hargreaves, Diana C.;Medzhitov, Ruslan
通讯作者：
Medzhitov, Ruslan
影响因子：
3.1
作者：
BISTONI, F;VECCHIARELLI, A;CASSONE, A
通讯作者：
CASSONE, A
影响因子：
5.4
作者：
Drummond, Rebecca A.;Saijo, Shinobu;Iwakura, Yoichiro;Brown, Gordon D.
通讯作者：
Brown, Gordon D.
影响因子：
5.5
作者：
Garly, ML;Martins, CL;Aaby, P
通讯作者：
Aaby, P