Molecular Mechanisms Modulating the Phenotype of Macrophages and Microglia.
Molecular Mechanisms Modulating the Phenotype of Macrophages and Microglia.
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DOI：
10.3389/fimmu.2017.01520
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发表时间：
2017
影响因子：
7.3
通讯作者：
Guerau-de-Arellano M
中科院分区：
文献类型：
--
作者：
Amici SA;Dong J;Guerau-de-Arellano M
巨噬细胞和小胶质细胞在中枢神经系统发育、体内平衡和急性事件（如感染或损伤）中起着至关重要的作用。组织巨噬细胞和小胶质细胞的不同功能同样反映在不同的表型上。炎症/M1与溶解期/M2巨噬细胞模型已被广泛使用。然而，巨噬细胞功能的复杂性只能通过巨噬细胞多样化、可塑性和三维表型的存在来实现。了解组织巨噬细胞如何通过分子程序整合环境信号来定义病原体/损伤炎症反应，为更好地理解巨噬细胞的多层性质以及靶向和调节细胞程序来控制过度炎症提供了机会。这在多发性硬化症和其他神经炎性疾病中尤为重要，在这些疾病中，慢性炎症性巨噬细胞和小胶质细胞反应可能导致病理。在这里，我们全面回顾了我们目前对分子途径如何调节组织巨噬细胞表型的理解，包括经典途径和microrna，受体酪氨酸激酶和巨噬细胞表型代谢的新作用。此外，我们还讨论了小胶质细胞的通路相似性，有助于识别外周巨噬细胞与小胶质细胞的新标记以及与它们的表型相关的标记。
Macrophages and microglia play crucial roles during central nervous system development, homeostasis and acute events such as infection or injury. The diverse functions of tissue macrophages and microglia are mirrored by equally diverse phenotypes. A model of inflammatory/M1 versus a resolution phase/M2 macrophages has been widely used. However, the complexity of macrophage function can only be achieved by the existence of varied, plastic and tridimensional macrophage phenotypes. Understanding how tissue macrophages integrate environmental signals via molecular programs to define pathogen/injury inflammatory responses provides an opportunity to better understand the multilayered nature of macrophages, as well as target and modulate cellular programs to control excessive inflammation. This is particularly important in MS and other neuroinflammatory diseases, where chronic inflammatory macrophage and microglial responses may contribute to pathology. Here, we perform a comprehensive review of our current understanding of how molecular pathways modulate tissue macrophage phenotype, covering both classic pathways and the emerging role of microRNAs, receptor-tyrosine kinases and metabolism in macrophage phenotype. In addition, we discuss pathway parallels in microglia, novel markers helpful in the identification of peripheral macrophages versus microglia and markers linked to their phenotype.
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影响因子：
3.6
作者：
Boonyatecha N;Sangphech N;Wongchana W;Kueanjinda P;Palaga T
通讯作者：
Palaga T
DOI：
10.4049/jimmunol.1202496
发表时间：
2013-06-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Banerjee S;Xie N;Cui H;Tan Z;Yang S;Icyuz M;Abraham E;Liu G
通讯作者：
Liu G
影响因子：
29
作者：
Bouhlel, M. Amine;Derudas, Bruno;Chinetti-Gbaguidi, Giulia
通讯作者：
Chinetti-Gbaguidi, Giulia
影响因子：
14.9
作者：
Adhikary T;Wortmann A;Schumann T;Finkernagel F;Lieber S;Roth K;Toth PM;Diederich WE;Nist A;Stiewe T;Kleinesudeik L;Reinartz S;Müller-Brüsselbach S;Müller R
通讯作者：
Müller R
影响因子：
25
作者：
Butovsky, Oleg;Jedrychowski, Mark P.;Moore, Craig S.;Cialic, Ron;Lanser, Amanda J.;Gabriely, Galina;Koeglsperger, Thomas;Dake, Ben;Wu, Pauline M.;Doykan, Camille E.;Fanek, Zain;Liu, LiPing;Chen, Zhuoxun;Rothstein, Jeffrey D.;Ransohoffl, Richard M.;Gygi, Steven P.;Antel, Jack P.;Weiner, Howard L.
通讯作者：
Weiner, Howard L.