Organoids and organs-on-chips: insights into predicting the efficacy of systemic treatment in colorectal cancer.
Organoids and organs-on-chips: insights into predicting the efficacy of systemic treatment in colorectal cancer.
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DOI：
10.1038/s41420-023-01354-9
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发表时间：
2023-02-22
影响因子：
7
通讯作者：
Chu, Xiaoyuan
中科院分区：
文献类型：
--
作者：
Zhu, Jialong;Ji, Linlin;Chen, Yitian;Li, Huiyu;Huang, Mengxi;Dai, Zhe;Wang, Jing;Xiang, Dan;Fu, Gongbo;Lei, Zengjie;Chu, Xiaoyuan
肿瘤的异质性对传统的肿瘤治疗提出了巨大的挑战，尤其是患者之间和患者内部的肿瘤异质性的再现尤为关键。基于此，个性化治疗已成为近年来乃至未来的重要研究热点。与肿瘤相关的治疗模型正在发展中，包括细胞系、患者来源的异种移植、有机类化合物等。有机类化合物是近十几年来出现的三维体外模型，能够再现原始肿瘤的细胞和分子组成。这些优势显示了患者衍生的有机化合物在开发个性化抗癌治疗方面的巨大潜力，包括临床前药物筛选和患者治疗反应的预测。微环境对癌症治疗的影响不容小觑，微环境的重塑也使有机物质与其他技术相互作用，芯片器官就是其中的代表。本文从临床疗效可预测性的角度，重点介绍了有机化合物和芯片上器官作为辅助参考工具在结直肠癌治疗中的应用。我们还讨论了这两种技术的局限性以及它们如何很好地互补。
Cancer heterogeneity has posed a great challenge to traditional cancer treatment, with the reappearance of cancer heterogeneity of inter and intra patients being especially critical. Based on this, personalized therapy has emerged as significant research focus in recent and even future years. Cancer-related therapeutic models are developing, including cell lines, patient-derived xenografts, organoids, etc. Organoids are three-dimensional in vitro models emerged in the past dozen years and are able to reproduce the cellular and molecular composition of the original tumor. These advantages demonstrate the great potential for patient-derived organoids to develop personalized anticancer therapies, including preclinical drug screening and the prediction of patient treatment response. The impact of microenvironment on cancer treatment cannot be underestimated, and the remodeling of microenvironment also allows organoids to interact with other technologies, among which organs-on-chips is a representative one. This review highlights the use of organoids and organs-on-chips as complementary reference tools in treating colorectal cancer from the perspective of clinical efficacy predictability. We also discuss the limitations of both techniques and how they complement each other well.
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