Dynamic changes in phase-amplitude coupling facilitate spatial attention control in fronto-parietal cortex.
Dynamic changes in phase-amplitude coupling facilitate spatial attention control in fronto-parietal cortex.
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DOI：
10.1371/journal.pbio.1001936
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发表时间：
2014-08
期刊：
影响因子：
9.8
通讯作者：
Knight RT
中科院分区：
文献类型：
--
作者：
Szczepanski SM;Crone NE;Kuperman RA;Auguste KI;Parvizi J;Knight RT
皮层脑电图揭示了两种神经元振荡频率之间的耦合如何使大脑皮层的额叶和顶叶区域随时控制人脑中的视觉注意力。注意力是一种核心的认知机制，它允许大脑根据当前的任务需求分配有限的资源。在人类和非人类灵长类动物的注意力分配过程中，额叶和后顶叶皮质区（统称为额顶叶注意力控制网络）参与其中。许多研究已经使用各种神经成像和头皮电生理技术检查了人类大脑中的这个网络。然而，很少有人知道这些额叶和顶叶区域如何动态地相互作用，以产生精细的时间（亚秒）和空间（亚厘米）尺度上的行为。我们讨论了人类额顶叶区域如何控制视觉空间的注意力在一个很好的时空尺度上记录皮层电图（ECoG）信号直接测量硬膜下电极阵列植入患者进行颅内监测癫痫灶的定位。受试者（n = 8）进行了空间线索任务，其中他们分配的视觉空间的注意，无论是右或左视野，并检测到的外观的目标。 我们发现高伽马（HG）功率（70-250 Hz）的增加时间锁定到试验开始，在整个注意力分配期间，额叶，顶叶和视觉区域保持升高。这些HG功率的增加是由注意力分配过程中正在进行的δ/θ（2-5 Hz）振荡的相位调制的。重要的是，我们发现，这种三角洲/θ相位HG振幅耦合的强度预测的反应时间检测到的目标上一个试验的基础上。这些结果突出了三角洲/θ相位HG振幅耦合的作用，作为一种机制，为亚秒级的促进和协调，在人类额顶叶皮层，是由瞬时注意力的需求。大脑皮层的额叶和顶叶区域控制着集中视觉空间注意力的能力，对这些区域的损伤会导致严重的注意力障碍。虽然许多研究都集中在这些区域的位置，但对这些区域如何在人类中发挥作用知之甚少。先前的研究已经表明，神经元尖峰更可能发生在特定的时间窗口，基于较低频率的神经振荡的相位-节奏或重复的神经元活动。这些低频节律被假设为协调局部和跨网络区域的神经元放电的时间。在这里，我们研究了人类额叶和顶叶皮质如何使用神经振荡来控制视觉空间注意力。我们确定了大脑电活动的高频成分，宽带高伽马（70-250 Hz）振幅，当研究对象注意周边视野时，它在额叶，顶叶和视觉区域上被锁相到较慢的节奏，δ/θ（2-5 Hz）。δ/θ相位和高γ振幅之间耦合强度的变化预测了单个试验中受试者的注意力行为。从这些结果中，我们得出结论，三角洲/θ相位和高伽玛振幅之间的耦合，协调信息内-也许之间-额叶和顶叶区域在分配的视觉空间注意。
Electrocorticography reveals how coupling between two frequencies of neuronal oscillation allows the frontal and parietal areas of the cortex to control visual attention from moment to moment in the human brain. Attention is a core cognitive mechanism that allows the brain to allocate limited resources depending on current task demands. A number of frontal and posterior parietal cortical areas, referred to collectively as the fronto-parietal attentional control network, are engaged during attentional allocation in both humans and non-human primates. Numerous studies have examined this network in the human brain using various neuroimaging and scalp electrophysiological techniques. However, little is known about how these frontal and parietal areas interact dynamically to produce behavior on a fine temporal (sub-second) and spatial (sub-centimeter) scale. We addressed how human fronto-parietal regions control visuospatial attention on a fine spatiotemporal scale by recording electrocorticography (ECoG) signals measured directly from subdural electrode arrays that were implanted in patients undergoing intracranial monitoring for localization of epileptic foci. Subjects (n = 8) performed a spatial-cuing task, in which they allocated visuospatial attention to either the right or left visual field and detected the appearance of a target. We found increases in high gamma (HG) power (70–250 Hz) time-locked to trial onset that remained elevated throughout the attentional allocation period over frontal, parietal, and visual areas. These HG power increases were modulated by the phase of the ongoing delta/theta (2–5 Hz) oscillation during attentional allocation. Critically, we found that the strength of this delta/theta phase-HG amplitude coupling predicted reaction times to detected targets on a trial-by-trial basis. These results highlight the role of delta/theta phase-HG amplitude coupling as a mechanism for sub-second facilitation and coordination within human fronto-parietal cortex that is guided by momentary attentional demands. The frontal and parietal areas of the cortex control the ability to focus visuospatial attention, and damage to these areas results in profound attentional disturbances. Although much research has concentrated on where these areas are located, little is known about how these areas may function in humans. Previous studies have demonstrated that neuronal spiking is more likely to occur in specific time windows based upon the phase of lower frequency neural oscillations – rhythmic or repetitive neuronal activity. These low-frequency rhythms are hypothesized to coordinate the timing of neuronal firing within local and across network regions. Here, we investigated how human frontal and parietal cortices use neural oscillations to control visuospatial attention. We identified a high-frequency component of electrical brain activity, broadband high gamma (70–250 Hz) amplitude, that became phase-locked to a slower rhythm, delta/theta (2–5 Hz), over frontal, parietal, and visual areas while the study subjects paid attention to the peripheral visual field. Changes in the strength of the coupling between delta/theta phase and high gamma amplitude predicted the attentional behavior of the subjects across single trials. From these results, we conclude that coupling between delta/theta phase and high gamma amplitude serves to coordinate information within – and perhaps between – frontal and parietal areas during allocation of visuospatial attention.
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影响因子：
3.7
作者：
Engell, Andrew D.;McCarthy, Gregory
通讯作者：
McCarthy, Gregory
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
影响因子：
56.9
作者：
Buschman, Timothy J.;Miller, Earl K.
通讯作者：
Miller, Earl K.
影响因子：
3.2
作者：
Cohen, Michael X.;Elger, Christian E.;Fell, Juergen
通讯作者：
Fell, Juergen
影响因子：
5.3
作者：
Dimigen, Olaf;Valsecchi, Matteo;Kliegl, Reinhold
通讯作者：
Kliegl, Reinhold