Adipose-derived stem cells: a review of signaling networks governing cell fate and regenerative potential in the context of craniofacial and long bone skeletal repair.
Adipose-derived stem cells: a review of signaling networks governing cell fate and regenerative potential in the context of craniofacial and long bone skeletal repair.
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脂肪来源的干细胞：在颅面和长骨骨骼修复背景下，对细胞命运和再生潜力的信号网络的综述。
DOI：
10.3390/ijms15069314
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发表时间：
2014-05-26
影响因子：
5.6
通讯作者：
Quarto N
中科院分区：
文献类型：
--
作者：
Senarath-Yapa K;McArdle A;Renda A;Longaker MT;Quarto N
医疗保健、营养和社会护理的改善正在导致世界人口结构发生值得称道的变化，人口老龄化的倾向越来越大。随着世界上被认为是老年人口的比例增加，骨退行性疾病的发病率也在增加，由此给医疗保健带来的负担也在增加。日益增长的需求加上当代方法的局限性，为开发新的组织再生疗法提供了动力。干细胞的使用具有自我更新和分化的潜力，是一种潜在的解决方案。脂肪干细胞(ASCs)是一种比较容易获取和容易获得的干细胞，是一种理想的候选干细胞。在这篇综述中，我们探索了ASCs为颅面和长骨骨骼缺陷提供切实治疗的潜力，概述了引导这些细胞的关键信号通路，并描述了发育信号程序如何在体内提供如何引导这些细胞的线索。这篇综述还概述了使用适当定制的支架建立成骨微核的重要性，并描述了成人干细胞骨骼再生治疗要成为临床现实仍需克服的一些关键挑战。
Improvements in medical care, nutrition and social care are resulting in a commendable change in world population demographics with an ever increasing skew towards an aging population. As the proportion of the world’s population that is considered elderly increases, so does the incidence of osteodegenerative disease and the resultant burden on healthcare. The increasing demand coupled with the limitations of contemporary approaches, have provided the impetus to develop novel tissue regeneration therapies. The use of stem cells, with their potential for self-renewal and differentiation, is one potential solution. Adipose-derived stem cells (ASCs), which are relatively easy to harvest and readily available have emerged as an ideal candidate. In this review, we explore the potential for ASCs to provide tangible therapies for craniofacial and long bone skeletal defects, outline key signaling pathways that direct these cells and describe how the developmental signaling program may provide clues on how to guide these cells in vivo. This review also provides an overview of the importance of establishing an osteogenic microniche using appropriately customized scaffolds and delineates some of the key challenges that still need to be overcome for adult stem cell skeletal regenerative therapy to become a clinical reality.
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影响因子：
--
作者：
Casadei A;Epis R;Ferroni L;Tocco I;Gardin C;Bressan E;Sivolella S;Vindigni V;Pinton P;Mucci G;Zavan B
通讯作者：
Zavan B
影响因子：
10.5
作者：
Akiyama, H;Chaboissier, MC;de Crombrugghe, B
通讯作者：
de Crombrugghe, B
影响因子：
2.8
作者：
de Girolamo, L.;Arrigoni, E.;Brini, A. T.
通讯作者：
Brini, A. T.
影响因子：
64.8
作者：
Conboy, IM;Conboy, MJ;Rando, TA
通讯作者：
Rando, TA
影响因子：
12.4
作者：
De Barros, Sandra;Dehez, Stephanie;Planat-Benard, Valerie
通讯作者：
Planat-Benard, Valerie