Measuring genome conservation across taxa: divided strains and united kingdoms.
Measuring genome conservation across taxa: divided strains and united kingdoms.
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DOI：
10.1093/nar/gki181
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发表时间：
2005
影响因子：
14.9
通讯作者：
Ouzounis CA
中科院分区：
文献类型：
--
作者：
Kunin V;Ahren D;Goldovsky L;Janssen P;Ouzounis CA
传统上，物种的进化关系是由系统发育标记分子的序列相似性定义的，最近基于基因顺序，平均正交相似性或基因含量，我们引入了基因组保护，这是全基因组的系统发育。同样，在整个基因组保存中，基因含量和序列相似性都代表了一个。稳健的距离测量，通过准确的系统发育重建，所有提出的测序生物的基因组保护矩阵表现出明显的定义所有分类范围评估的分类范围的进化关系的能力。将来可以使用更精确和定量的分类法。在基因组系统发育服务器上：<>。
Species evolutionary relationships have traditionally been defined by sequence similarities of phylogenetic marker molecules, recently followed by whole-genome phylogenies based on gene order, average ortholog similarity or gene content. Here, we introduce genome conservation—a novel metric of evolutionary distances between species that simultaneously takes into account, both gene content and sequence similarity at the whole-genome level. Genome conservation represents a robust distance measure, as demonstrated by accurate phylogenetic reconstructions. The genome conservation matrix for all presently sequenced organisms exhibits a remarkable ability to define evolutionary relationships across all taxonomic ranges. An assessment of taxonomic ranks with genome conservation shows that certain ranks are inadequately described and raises the possibility for a more precise and quantitative taxonomy in the future. All phylogenetic reconstructions are available at the genome phylogeny server: <>.
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影响因子：
56.9
作者：
FOX, GE;STACKEBRANDT, E;WOESE, CR
通讯作者：
WOESE, CR
影响因子：
56.9
作者：
DOOLITTLE, RF
通讯作者：
DOOLITTLE, RF
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3.9
作者：
Dutilh, BE;Huynen, MA;Snel, B
通讯作者：
Snel, B
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30.8
作者：
Snel, B;Bork, P;Huynen, MA
通讯作者：
Huynen, MA
影响因子：
5.8
作者：
Janssen, P;Enright, AJ;Ouzounis, CA
通讯作者：
Ouzounis, CA