Magnetic resonance diffusion characteristics of histologically defined prostate cancer in humans.
Magnetic resonance diffusion characteristics of histologically defined prostate cancer in humans.
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DOI：
10.1002/mrm.21896
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发表时间：
2009-04
影响因子：
3.3
通讯作者：
Song, Sheng-Kwei
中科院分区：
文献类型：
--
作者：
Xu, Junqian;Humphrey, Peter A.;Kibel, Adam S.;Snyder, Abraham Z.;Narra, Vamsidhar R.;Ackerman, Joseph J. H.;Song, Sheng-Kwei
关键词：
扩散敏感磁共振提供的对比为器官受限的人前列腺癌（PCa）提供了改善肿瘤定位的希望。扩散张量成像（Diffusion tensor imaging， DTI）测量的前列腺癌分别在体内、根治性前列腺切除术患者中进行，随后在离体、同一患者的前列腺切除术标本中进行。成像数据与前列腺切除术标本的组织学切片共同登记，从而能够明确表征癌组织和良性组织中的扩散参数。在体内和离体情况下，与良性外周区组织相比，外周区PCa细胞密度增加，从而减少腔隙，分别导致表观扩散策略（ADC）降低约40%和50%。相比之下，在癌组织和非癌组织之间没有明显的扩散各向异性差异。而前列腺内致密的纤维肌肉组织，如中央腺良性前列腺增生的间质组织，则表现出较高的扩散各向异性。提出了一种结合DTI和t2加权图像对比度的组织分类方法，该方法可以提供比单独t2加权成像更高的PCa检测特异性。在体积呈现的磁共振图像中识别的前列腺癌与组织学上确定的前列腺癌病灶定性相关。
The contrast provided by diffusion-sensitive magnetic resonance offers the promise of improved tumor localization in organ-confined human prostate cancer (PCa). Diffusion tensor imaging (DTI) measurements of PCa were performed in vivo, in patients undergoing radical prostatectomy, and later, ex vivo, in the same patients’ prostatectomy specimens. The imaging data were coregistered to histological sections of the prostatectomy specimens, thereby enabling unambiguous characterization of diffusion parameters in cancerous and benign tissues. Increased cellularity, and hence decreased luminal spaces, in peripheral zone PCa led to approximately 40% and 50% apparent diffusion policy (ADC) decrease compared with benign peripheral zone tissues in vivo and ex vivo, respectively. In contrast, no significant diffusion anisotropy differences were observed between the cancerous and noncancerous peripheral zone tissues. However, the dense fibromuscular tissues in prostate, such as stromal tissues in benign prostatic hyperplasia in central gland, exhibited high diffusion anisotropy. A tissue classification method is proposed to combine DTI and T2-weighted image contrasts that may provide improved specificity of PCa detection over T2-weighted imaging alone. PCa identified in volume rendered MR images qualitatively correlates well with histologically determined PCa foci.
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影响因子：
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作者：
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