Dopamine receptor DOP-1 engages a sleep pathway to modulate swimming in C. elegans.
Dopamine receptor DOP-1 engages a sleep pathway to modulate swimming in C. elegans.
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多巴胺受体 DOP-1 参与睡眠途径来调节秀丽隐杆线虫的游泳
DOI：
10.1016/j.isci.2021.102247
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发表时间：
2021-04-23
期刊：
影响因子：
5.8
通讯作者：
Bai J
中科院分区：
文献类型：
--
作者：
Xu Y;Zhang L;Liu Y;Topalidou I;Hassinan C;Ailion M;Zhao Z;Wang T;Chen Z;Bai J
动物需要强大而灵活的程序来支持运动。在这里，我们报告了一条将D1样多巴胺受体DOP-1与睡眠机制连接起来的途径，以调节线虫的游泳。我们发现DOP-1在维持游泳行为中起着负面作用。相比之下，通过D2样多巴胺受体DOP-3的途径对游泳的启动进行负面调节，但其影响在几分钟内迅速消退。我们发现DOP-1和GPCRK(G蛋白偶联受体激酶-2)在睡眠中间神经元RIS中起作用，其中DOP-1调节睡眠神经肽FLP-11的分泌。我们进一步证明DOP-1和FLP-11在调节游泳方面具有相同的作用途径。总而言之，这些结果描绘了多巴胺受体和睡眠程序之间的功能联系，以调节线虫的游泳。DOP-3和DOP-1通路之间的时间转换突显了随着时间的推移，神经调节对有节奏的运动的动态性质。D1样多巴胺受体DOP-1调节10分钟的游泳DOP-1和DOP-3的整合功能是游泳的持续性所必需的DOP-1和GRK-2在睡眠神经元中的作用RIS FLP-11，FLP-11是一种促进睡眠的神经肽，负向调节游泳生物科学；神经科学；行为神经科学
Animals require robust yet flexible programs to support locomotion. Here we report a pathway that connects the D1-like dopamine receptor DOP-1 with a sleep mechanism to modulate swimming in C. elegans. We show that DOP-1 plays a negative role in sustaining swimming behavior. By contrast, a pathway through the D2-like dopamine receptor DOP-3 negatively regulates the initiation of swimming, but its impact fades quickly over a few minutes. We find that DOP-1 and the GPCR kinase (G-protein-coupled receptor kinase-2) function in the sleep interneuron RIS, where DOP-1 modulates the secretion of a sleep neuropeptide FLP-11. We further show that DOP-1 and FLP-11 act in the same pathway to modulate swimming. Together, these results delineate a functional connection between a dopamine receptor and a sleep program to regulate swimming in C. elegans. The temporal transition between DOP-3 and DOP-1 pathways highlights the dynamic nature of neuromodulation for rhythmic movements that persist over time. The D1-like dopamine receptor DOP-1 regulates swimming at 10 min An integrated function of DOP-1 and DOP-3 is required for the continuity of swimming DOP-1 and GRK-2 act in the sleep neuron RIS FLP-11, a neuropeptide that promotes sleep, negatively regulates swimming Biological Sciences ; Neuroscience ; Behavioral Neuroscience
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分析突触蛋白鉴定了胰岛素分泌和寿命的调节剂。
影响因子：
4.5
作者：
Ch'ng, QueeLim;Sieburth, Derek;Kaplan, Joshua M.
通讯作者：
Kaplan, Joshua M.
影响因子：
56.9
作者：
DELCOMYN, F
通讯作者：
DELCOMYN, F
DOI：
10.1101/lm.041830.116
发表时间：
2016-10
期刊：
Learning & memory (Cold Spring Harbor, N.Y.)
影响因子：
--
作者：
Ardiel EL;Giles AC;Yu AJ;Lindsay TH;Lockery SR;Rankin CH
通讯作者：
Rankin CH
传入的神经肽系统会传输机械感觉信号，从而触发敏感性和秀丽隐杆线虫的唤醒。
影响因子：
16.2
作者：
Chew YL;Tanizawa Y;Cho Y;Zhao B;Yu AJ;Ardiel EL;Rabinowitch I;Bai J;Rankin CH;Lu H;Beets I;Schafer WR
通讯作者：
Schafer WR
影响因子：
64.8
作者：
Funato H;Miyoshi C;Fujiyama T;Kanda T;Sato M;Wang Z;Ma J;Nakane S;Tomita J;Ikkyu A;Kakizaki M;Hotta-Hirashima N;Kanno S;Komiya H;Asano F;Honda T;Kim SJ;Harano K;Muramoto H;Yonezawa T;Mizuno S;Miyazaki S;Connor L;Kumar V;Miura I;Suzuki T;Watanabe A;Abe M;Sugiyama F;Takahashi S;Sakimura K;Hayashi Y;Liu Q;Kume K;Wakana S;Takahashi JS;Yanagisawa M
通讯作者：
Yanagisawa M