An Afferent Neuropeptide System Transmits Mechanosensory Signals Triggering Sensitization and Arousal in C. elegans.
An Afferent Neuropeptide System Transmits Mechanosensory Signals Triggering Sensitization and Arousal in C. elegans.
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传入的神经肽系统会传输机械感觉信号，从而触发敏感性和秀丽隐杆线虫的唤醒。
DOI：
10.1016/j.neuron.2018.08.003
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发表时间：
2018-09-19
期刊：
影响因子：
16.2
通讯作者：
Schafer WR
中科院分区：
文献类型：
--
作者：
Chew YL;Tanizawa Y;Cho Y;Zhao B;Yu AJ;Ardiel EL;Rabinowitch I;Bai J;Rankin CH;Lu H;Beets I;Schafer WR
敏化是行为可塑性的一种简单形式，通过这种形式，最初的刺激（通常是危险信号）会导致对后续刺激的反应增强。跨模态敏化是许多生物体觉醒的一个重要特征，但其分子和神经机制尚不完全清楚。在这里，我们表明，在秀丽隐杆线虫，厌恶的机械刺激导致增强的运动活动和厌恶的化学感受途径的敏化。运动唤醒和跨模态敏化都依赖于初级机械感觉神经元及其受体FRPR-3释放FLP-20神经肽。令人惊讶的是，FRPR-3对感觉和运动唤醒的关键作用部位是RID，这是一种专门用于释放神经肽的单一神经内分泌细胞，其以FLP-20依赖性方式响应机械刺激。因此，FLP-20肽作为传入唤醒信号，将机械感觉信息传递给调节唤醒和其他行为状态的中枢神经元。秀丽隐杆线虫中的一种新的唤醒范式需要神经肽信号级联机制感觉刺激导致持久的运动和感觉敏化唤醒需要由触觉神经元和受体FRPR-3释放的FLP-20肽FRPR-3活性然后通过中间神经元RID赋予行为状态信息唤醒是一种重要的保守行为状态，其中动物表现出增加的感觉反应性和运动机能亢进。Chew等人鉴定神经调节通路，其使得机械感觉神经元能够通过激活神经内分泌中心来促进感觉和运动唤醒。
Sensitization is a simple form of behavioral plasticity by which an initial stimulus, often signaling danger, leads to increased responsiveness to subsequent stimuli. Cross-modal sensitization is an important feature of arousal in many organisms, yet its molecular and neural mechanisms are incompletely understood. Here we show that in C. elegans, aversive mechanical stimuli lead to both enhanced locomotor activity and sensitization of aversive chemosensory pathways. Both locomotor arousal and cross-modal sensitization depend on the release of FLP-20 neuropeptides from primary mechanosensory neurons and on their receptor FRPR-3. Surprisingly, the critical site of action of FRPR-3 for both sensory and locomotor arousal is RID, a single neuroendocrine cell specialized for the release of neuropeptides that responds to mechanical stimuli in a FLP-20-dependent manner. Thus, FLP-20 peptides function as an afferent arousal signal that conveys mechanosensory information to central neurons that modulate arousal and other behavioral states. A novel arousal paradigm in C. elegans requires a cascade of neuropeptide signaling Mechanosensory stimulation leads to long-lasting motor and sensory sensitization Arousal requires FLP-20 peptides released by touch neurons and receptor FRPR-3 FRPR-3 activity then confers behavioral state information via the interneuron RID Arousal is an important conserved behavioral state where animals show increased sensory responsiveness and locomotor hyperactivity. Chew et al. identify a neuromodulatory pathway that enables mechanosensory neurons to promote both sensory and locomotor arousal via activation of a neuroendocrine center.
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影响因子：
64.5
作者：
Asahina K;Watanabe K;Duistermars BJ;Hoopfer E;González CR;Eyjólfsdóttir EA;Perona P;Anderson DJ
通讯作者：
Anderson DJ
影响因子：
9.8
作者：
Donnelly JL;Clark CM;Leifer AM;Pirri JK;Haburcak M;Francis MM;Samuel AD;Alkema MJ
通讯作者：
Alkema MJ
影响因子：
5.2
作者：
Elphick MR;Mirabeau O
通讯作者：
Mirabeau O
影响因子：
2.7
作者：
Aime, P.;Duchamp-Viret, P.;Julliard, A. K.
通讯作者：
Julliard, A. K.
影响因子：
56.9
作者：
Beets, Isabel;Janssen, Tom;Schoofs, Liliane
通讯作者：
Schoofs, Liliane