Molecular electronic tuning of photosensitizers to enhance photodynamic therapy: synthetic dicyanobacteriochlorins as a case study.
Molecular electronic tuning of photosensitizers to enhance photodynamic therapy: synthetic dicyanobacteriochlorins as a case study.
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DOI：
10.1111/php.12021
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发表时间：
2013-05
影响因子：
3.3
通讯作者：
Holten D
中科院分区：
文献类型：
--
作者：
Yang E;Diers JR;Huang YY;Hamblin MR;Lindsey JS;Bocian DF;Holten D
光物理，光稳定性，电化学，和分子轨道特性进行了分析，一组稳定的双氰菌绿，是有前途的光敏剂光动力疗法（PDT）。细菌绿素是母体化合物（BC）、二氰基衍生物（NC）2BC和相应的锌（NC）2BC-Zn和钯螯合物（NC）2BC-Pd。PDT对HeLa人癌细胞的体外杀伤活性顺序为（NC）2BC-Pd >（NC）2BC >（NC）2BC-Zn-Pd-BC。每种双氰菌绿素的近红外吸收特征从BC的近红外吸收特征（713 nm）向红移35-50 nm（748-763 nm）。对于（NC）2BC-Pd，到PDT活性三重激发态的系间穿越基本上是定量的。来自（NC）2BC-Pd的磷光发生在1122 nm（1.1 eV）。该值和测量的基态氧化还原电位固定三重激发态氧化还原性质，其通过1型（电子转移）途径支持PDT活性。一个可能违反直觉（但容易解释）的结果是，在三种双氰菌绿中，具有最短三重态寿命（7 μs）的光敏剂（NC）2BC-Pd具有最高的活性。从聚集、还原、氧化和化学反应4个方面对双氰菌绿素和其它细菌绿素的光稳定性进行了研究和讨论。总的来说，结果和分析提供了有关PDT药物的分子设计的基本见解。
Photophysical, photostability, electrochemical, and molecular-orbital characteristics are analyzed for a set of stable dicyanobacteriochlorins that are promising photosensitizers for photodynamic therapy (PDT). The bacteriochlorins are the parent compound (BC), dicyano derivative (NC)2BC and corresponding zinc (NC)2BC-Zn and palladium chelate (NC)2BC-Pd. The order of PDT activity against HeLa human cancer cells in vitro is (NC)2BC-Pd > (NC)2BC > (NC)2BC-Zn ≈ BC. The near-infrared absorption feature of each dicyanobacteriochlorin is bathochromically shifted 35–50 nm (748–763 nm) from that for BC (713 nm). Intersystem crossing to the PDT-active triplet excited state is essentially quantitative for (NC)2BC-Pd. Phosphorescence from (NC)2BC-Pd occurs at 1122 nm (1.1 eV). This value and the measured ground-state redox potentials fix the triplet excited-state redox properties, which underpin PDT activity via Type-1 (electron-transfer) pathways. A perhaps counterintuitive (but readily explicable) result is that of the three dicyanobacteriochlorins, the photosensitizer with the shortest triplet lifetime (7 μs), (NC)2BC-Pd, has the highest activity. Photostabilities of the dicyanobacteriochlorins and other bacteriochlorins studied recently are investigated and discussed in terms of four phenomena: aggregation, reduction, oxidation, and chemical reaction. Collectively, the results and analysis provide fundamental insights concerning the molecular design of PDT agents.
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影响因子：
7.3
作者：
Huang, Ying-Ying;Mroz, Pawel;Zhiyentayev, Timur;Sharma, Sulbha K.;Balasubramanian, Thiagarajan;Ruzie, Christian;Krayer, Michael;Fan, Dazhong;Borbas, K. Eszter;Yang, Eunkyung;Kee, Hooi Ling;Kirmaier, Christine;Diers, James R.;Bocian, David F.;Holten, Dewey;Lindsey, Jonathan S.;Hamblin, Michael R.
通讯作者：
Hamblin, Michael R.
DOI：
10.3322/caac.20114
发表时间：
2011-07
期刊：
CA: a cancer journal for clinicians
影响因子：
--
作者：
Agostinis P;Berg K;Cengel KA;Foster TH;Girotti AW;Gollnick SO;Hahn SM;Hamblin MR;Juzeniene A;Kessel D;Korbelik M;Moan J;Mroz P;Nowis D;Piette J;Wilson BC;Golab J
通讯作者：
Golab J
影响因子：
4.9
作者：
Huang, Liyi;Huang, Ying-Ying;Hamblin, Michael R.
通讯作者：
Hamblin, Michael R.
影响因子：
3.3
作者：
Mass, Olga;Taniguchi, Masahiko;Lindsey, Jonathan S.
通讯作者：
Lindsey, Jonathan S.
影响因子：
4.8
作者：
Mroz, Pawel;Huang, Ying-Ying;Hamblin, Michael R.
通讯作者：
Hamblin, Michael R.