Photodynamic therapy of cancer: an update.
Photodynamic therapy of cancer: an update.
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DOI：
10.3322/caac.20114
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发表时间：
2011-07
期刊：
影响因子：
--
通讯作者：
Golab J
中科院分区：
文献类型：
--
作者：
Agostinis P;Berg K;Cengel KA;Foster TH;Girotti AW;Gollnick SO;Hahn SM;Hamblin MR;Juzeniene A;Kessel D;Korbelik M;Moan J;Mroz P;Nowis D;Piette J;Wilson BC;Golab J
光动力疗法（PDT）是一种临床批准的微创治疗方法，可以对恶性细胞发挥选择性细胞毒活性。该方法包括施用光敏剂，然后在对应于敏化剂的吸收带的波长下照射。在氧气存在的情况下，一系列事件导致直接肿瘤细胞死亡、微血管损伤和诱导局部炎症反应。临床研究表明，光动力疗法可以治愈，特别是在早期肿瘤。它可以延长无法手术的癌症的生存期，并显着提高生活质量。最小的正常组织毒性、可忽略的全身效应、大大降低的长期发病率、缺乏内在或获得性耐药机制、以及该治疗的优异的美容和器官功能保留效应使其成为组合治疗的有价值的治疗选择。随着一些最新的技术进步，PDT有可能成为整合到主流的癌症治疗。
Photodynamic therapy (PDT) is a clinically approved, minimally invasive therapeutic procedure that can exert a selective cytotoxic activity toward malignant cells. The procedure involves administration of a photosensitizing agent followed by irradiation at a wavelength corresponding to an absorbance band of the sensitizer. In the presence of oxygen, a series of events lead to direct tumor cell death, damage to the microvasculature and induction of a local inflammatory reaction. Clinical studies revealed that PDT can be curative particularly in early-stage tumors. It can prolong survival in inoperable cancers and significantly improve quality of life. Minimal normal tissue toxicity, negligible systemic effects, greatly reduced long-term morbidity, lack of intrinsic or acquired resistance mechanisms, and excellent cosmetic as well as organ function-sparing effects of this treatment make it a valuable therapeutic option for combination treatments. With a number of recent technological improvements, PDT has the potential to become integrated into the mainstream of cancer treatment.
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影响因子：
--
作者：
Cengel, K A;Glatstein, E;Hahn, S M
通讯作者：
Hahn, S M
影响因子：
13.3
作者：
Buytaert, E.;Callewaert, G.;Agostinis, P.
通讯作者：
Agostinis, P.
影响因子：
2.1
作者：
Brancaleon, L;Moseley, H
通讯作者：
Moseley, H
影响因子：
3.1
作者：
Bhuvaneswari, Ramaswamy;Yuen, Gan Yik;Olivo, Malini
通讯作者：
Olivo, Malini
影响因子：
2.5
作者：
Basset-Seguin, Nicole;Ibbotson, Sally H.;Wolf, Peter
通讯作者：
Wolf, Peter