Cellular and molecular mechanisms of negligible senescence: insight from the sea urchin.
Cellular and molecular mechanisms of negligible senescence: insight from the sea urchin.
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DOI：
10.1080/07924259.2014.938195
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发表时间：
2015-01-30
影响因子：
0.8
通讯作者：
Bodnar AG
中科院分区：
文献类型：
--
作者：
Bodnar AG
海胆表现出与人类和短命模型动物非常不同的生活史，因此提供了对复杂衰老过程的新见解的机会。海胆的生长不确定，再生受损的附属物，并在其整个生命周期中繁殖。有些物种在高龄时死亡率没有增加。尽管如此，不同种类的海胆有非常不同的报告寿命范围从4到100多年，从而提供了一个独特的模型来研究分子，细胞和生理机制的寿命决定和可忽略的衰老。迄今为止的研究表明，在具有不同寿命的海胆物种的组织中，端粒的维持、抗氧化剂和蛋白酶体酶活性的维持以及随着年龄的氧化细胞损伤的少量积累。基因表达研究表明，参与能量代谢、蛋白质稳态和组织再生的关键细胞途径随着年龄的增长而维持。总之，这些研究表明，长期维持维持组织稳态和再生能力的机制对于不确定的生长和可忽略的衰老是必不可少的，并且更好地了解这些过程可能会提出有效的策略来减轻人体组织随年龄的退行性衰退。
Sea urchins exhibit a very different life history from humans and short-lived model animals and therefore provide the opportunity to gain new insight into the complex process of aging. Sea urchins grow indeterminately, regenerate damaged appendages, and reproduce throughout their lifespan. Some species show no increase in mortality rate at advanced ages. Nevertheless, different species of sea urchins have very different reported lifespans ranging from 4 to more than 100 years, thus providing a unique model to investigate the molecular, cellular, and physiological mechanisms underlying both lifespan determination and negligible senescence. Studies to date have demonstrated maintenance of telomeres, maintenance of antioxidant and proteasome enzyme activities, and little accumulation of oxidative cellular damage with age in tissues of sea urchin species with different lifespans. Gene expression studies indicate that key cellular pathways involved in energy metabolism, protein homeostasis, and tissue regeneration are maintained with age. Taken together, these studies suggest that long-term maintenance of mechanisms that sustain tissue homeostasis and regenerative capacity is essential for indeterminate growth and negligible senescence, and a better understanding of these processes may suggest effective strategies to mitigate the degenerative decline in human tissues with age.
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影响因子：
64.5
作者：
López-Otín C;Blasco MA;Partridge L;Serrano M;Kroemer G
通讯作者：
Kroemer G
影响因子：
11.1
作者：
Carlson, Morgan E.;Suetta, Charlotte;Conboy, Michael J.;Aagaard, Per;Mackey, Abigail;Kjaer, Michael;Conboy, Irina
通讯作者：
Conboy, Irina
DOI：
10.1046/j.1439-0485.2000.00688.x
发表时间：
2000-05-01
期刊：
MARINE ECOLOGY-PUBBLICAZIONI DELLA STAZIONE ZOOLOGICA DI NAPOLI I
影响因子：
--
作者：
Beddingfield, SD;McClintock, JB
通讯作者：
McClintock, JB
影响因子：
3.9
作者：
Ebert, Thomas A.
通讯作者：
Ebert, Thomas A.
影响因子：
56.9
作者：
Brack, Andrew S.;Conboy, Michael J.;Rando, Thomas A.
通讯作者：
Rando, Thomas A.