The hallmarks of aging.
The hallmarks of aging.
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DOI：
10.1016/j.cell.2013.05.039
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发表时间：
2013-06-06
期刊：
影响因子：
64.5
通讯作者：
Kroemer G
中科院分区：
文献类型：
--
作者：
López-Otín C;Blasco MA;Partridge L;Serrano M;Kroemer G
衰老的特征是生理完整性的逐渐丧失，导致功能受损和死亡的脆弱性增加。这种恶化是包括癌症、糖尿病、心血管疾病和神经退行性疾病在内的主要人类病理学的主要风险因素。近年来，衰老研究取得了前所未有的进展，特别是发现衰老的速度至少在一定程度上受到进化中保守的遗传途径和生化过程的控制。这篇综述列举了9个代表不同生物体中常见衰老因子的暂定标志，特别强调了哺乳动物的衰老。这些特点是：基因组不稳定性、端粒磨损、表观遗传改变、蛋白质稳态丧失、营养感应失调、线粒体功能障碍、细胞衰老、干细胞衰竭和细胞间通讯改变。一个主要的挑战是剖析候选标志之间的相互联系及其对衰老的相对贡献，最终目标是确定药物靶点，以改善衰老过程中的人类健康，同时副作用最小。
Aging is characterized by a progressive loss of physiological integrity, leading to impaired function and increased vulnerability to death. This deterioration is the primary risk factor for major human pathologies including cancer, diabetes, cardiovascular disorders, and neurodegenerative diseases. Aging research has experienced an unprecedented advance over recent years, particularly with the discovery that the rate of aging is controlled, at least to some extent, by genetic pathways and biochemical processes conserved in evolution. This review enumerates nine tentative hallmarks that represent common denominators of aging in different organisms, with special emphasis on mammalian aging. These hallmarks are: genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, deregulated nutrient-sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and altered intercellular communication. A major challenge is to dissect the interconnectedness between the candidate hallmarks and their relative contribution to aging, with the final goal of identifying pharmaceutical targets to improve human health during aging with minimal side-effects.
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影响因子：
4.5
作者：
Ameur A;Stewart JB;Freyer C;Hagström E;Ingman M;Larsson NG;Gyllensten U
通讯作者：
Gyllensten U
影响因子：
8.8
作者：
Brown K;Xie S;Qiu X;Mohrin M;Shin J;Liu Y;Zhang D;Scadden DT;Chen D
通讯作者：
Chen D
DOI：
10.18632/aging.100273
发表时间：
2011-02
期刊：
Aging
影响因子：
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作者：
Anisimov VN;Berstein LM;Popovich IG;Zabezhinski MA;Egormin PA;Piskunova TS;Semenchenko AV;Tyndyk ML;Yurova MN;Kovalenko IG;Poroshina TE
通讯作者：
Poroshina TE
影响因子：
64.8
作者：
Burnett, Camilla;Valentini, Sara;Cabreiro, Filipe;Goss, Martin;Somogyvari, Milan;Piper, Matthew D.;Hoddinott, Matthew;Sutphin, George L.;Leko, Vid;McElwee, Joshua J.;Vazquez-Manrique, Rafael P.;Orfila, Anne-Marie;Ackerman, Daniel;Au, Catherine;Vinti, Giovanna;Riesen, Michele;Howard, Ken;Neri, Christian;Bedalov, Antonio;Kaeberlein, Matt;Soti, Csaba;Partridge, Linda;Gems, David
通讯作者：
Gems, David
DOI：
10.1038/nrg3246
发表时间：
2012-10
期刊：
Nature reviews. Genetics
影响因子：
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作者：
通讯作者：
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