Changes in Gut Microbiota-Related Metabolites and Long-term Successful Weight Loss in Response to Weight-Loss Diets: The POUNDS Lost Trial.
Changes in Gut Microbiota-Related Metabolites and Long-term Successful Weight Loss in Response to Weight-Loss Diets: The POUNDS Lost Trial.
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DOI：
10.2337/dc17-2108
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发表时间：
2018-03
期刊：
影响因子：
16.2
通讯作者：
Qi L
中科院分区：
文献类型：
--
作者：
Heianza Y;Sun D;Smith SR;Bray GA;Sacks FM;Qi L
肥胖和肠道微生物群都与2型糖尿病的风险有关。我们的目的是全面研究减肥饮食干预引起的肠道微生物群相关代谢物的变化，如三甲胺N-氧化物（TMAO）及其前体（胆碱和左旋肉碱），与肥胖和局部脂肪沉积的改善有关。这项研究包括510名超重和肥胖的人，他们被随机分配到四种不同的大量营养素摄入量的饮食中。我们研究了6个月血液代谢物（TMAO，胆碱和左旋肉碱）的变化与体重（BW），腰围（WC），体脂组成，脂肪分布和静息能量消耗（REE）的改善之间的关系。与TMAO相比，胆碱（P < 0.0001）和左旋肉碱（P < 0.01）降低幅度更大的个体在6个月时显示出BW和WC的显著损失。胆碱的减少是显着的预测减少身体脂肪组成，脂肪分布，和REE。敏感性分析结果显示，基线糖尿病风险状态，如高血糖（占总参与者的31%）和空腹血糖水平的存在，并没有改变相关性。胆碱和左旋肉碱的早期变化对2年以上的体重减轻有显著预测作用（P < 0.05）。胆碱或左旋肉碱增加的个体在2年内无法减肥（-5%或更多损失）的可能性增加2.35倍（95%CI 1.38，4.00）或1.77倍（1.06，2.95）。超重和肥胖的人谁表现出循环胆碱或左旋肉碱水平下降实现了更大的改善肥胖和能量代谢通过吃低热量减肥饮食，这表明，这种代谢物是预测个人的治疗反应。进一步的调查是必要的，以证实我们的研究结果，特别是在糖尿病前期人群，这是更有代表性的美国肥胖人口。
Adiposity and the gut microbiota are both related to the risk of type 2 diabetes. We aimed to comprehensively examine how changes induced by a weight-loss diet intervention in gut microbiota–related metabolites, such as trimethylamine N-oxide (TMAO) and its precursors (choline and l-carnitine), were associated with improvements in adiposity and regional fat deposition. This study included 510 overweight and obese individuals who were randomly assigned one of four diets varying in macronutrient intake. We examined associations of 6-month changes in blood metabolites (TMAO, choline, and l-carnitine) with improvements in body weight (BW), waist circumference (WC), body fat composition, fat distribution, and resting energy expenditure (REE). Individuals with a greater reduction of choline (P < 0.0001) and l-carnitine (P < 0.01) rather than TMAO showed significant losses of BW and WC at 6 months. The reduction of choline was significantly predictive of decreases in body fat composition, fat distribution, and REE. Results of sensitivity analysis showed that the baseline diabetes risk status, such as the presence of hyperglycemia (31% of the total participants) and fasting glucose levels, did not modify the associations. Early changes in choline and l-carnitine were significantly predictive of weight loss over 2 years (P < 0.05 for all). Individuals with increases in choline or l-carnitine were 2.35-times (95% CI 1.38, 4.00) or 1.77-times (1.06, 2.95) more likely to fail to lose weight (–5% or more loss) at 2 years. Overweight and obese individuals who showed decreases in circulating choline or l-carnitine levels achieved greater improvements of adiposity and energy metabolism by eating a low-calorie weight-loss diet, suggesting that such metabolites are predictive of individuals’ response to the treatment. Further investigations are necessary to confirm our findings, particularly in a population with prediabetes that is more representative of the U.S. population with obesity.
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影响因子：
37.8
作者：
Jensen MD;Ryan DH;Apovian CM;Ard JD;Comuzzie AG;Donato KA;Hu FB;Hubbard VS;Jakicic JM;Kushner RF;Loria CM;Millen BE;Nonas CA;Pi-Sunyer FX;Stevens J;Stevens VJ;Wadden TA;Wolfe BM;Yanovski SZ;Jordan HS;Kendall KA;Lux LJ;Mentor-Marcel R;Morgan LC;Trisolini MG;Wnek J;Anderson JL;Halperin JL;Albert NM;Bozkurt B;Brindis RG;Curtis LH;DeMets D;Hochman JS;Kovacs RJ;Ohman EM;Pressler SJ;Sellke FW;Shen WK;Smith SC Jr;Tomaselli GF;American College of Cardiology/American Heart Association Task Force on Practice Guidelines;Obesity Society
通讯作者：
Obesity Society
影响因子：
3.7
作者：
Narath SH;Mautner SI;Svehlikova E;Schultes B;Pieber TR;Sinner FM;Gander E;Libiseller G;Schimek MG;Sourij H;Magnes C
通讯作者：
Magnes C
DOI：
10.1056/nejmoa1109400
发表时间：
2013-04-25
期刊：
The New England journal of medicine
影响因子：
--
作者：
Tang WH;Wang Z;Levison BS;Koeth RA;Britt EB;Fu X;Wu Y;Hazen SL
通讯作者：
Hazen SL
影响因子：
6.9
作者：
Boutagy, Nabil E.;Neilson, Andrew P.;Davy, Kevin P.
通讯作者：
Davy, Kevin P.
影响因子：
120.7
作者：
Menke, Andy;Casagrande, Sarah;Cowie, Catherine C.
通讯作者：
Cowie, Catherine C.