Does the use of chitosan contribute to oxalate kidney stone formation?
Does the use of chitosan contribute to oxalate kidney stone formation?
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DOI：
10.3390/md13010141
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发表时间：
2014-12-29
期刊：
影响因子：
5.4
通讯作者：
Rocha HA
中科院分区：
文献类型：
--
作者：
Fernandes Queiroz M;Melo KR;Sabry DA;Sassaki GL;Rocha HA
壳聚糖由于其化学和药理学性质而广泛应用于生物医学领域。然而，摄入壳聚糖会导致肾组织中壳聚糖的蓄积，并促进钙排泄的增加。另一方面，壳聚糖对草酸钙晶体（CaOx）形成的影响尚未被描述。在这项工作中，我们评估了壳聚糖的抗氧化能力和其在体外形成的CaOx晶体的干扰。这里，商业上获得的壳聚糖通过核磁共振和红外光谱确认了其身份。在几个测试中，这种壳聚糖显示出低或没有抗氧化活性。然而，它也显示出优异的铜螯合活性。在体外，壳聚糖作为主要的一水CaOx晶体形成的诱导剂，这是更普遍的尿石症患者。我们还观察到，壳聚糖改变了这些晶体的形态和大小，并改变了晶体的表面电荷，使它们更具正性，这可以促进这些晶体与肾细胞的相互作用。壳聚糖在体外对晶体的形成有很大影响，应进行体内分析以评估使用壳聚糖的风险。
Chitosan is widely used in the biomedical field due its chemical and pharmacological properties. However, intake of chitosan results in renal tissue accumulation of chitosan and promotes an increase in calcium excretion. On the other hand, the effect of chitosan on the formation of calcium oxalate crystals (CaOx) has not been described. In this work, we evaluated the antioxidant capacity of chitosan and its interference in the formation of CaOx crystals in vitro. Here, the chitosan obtained commercially had its identity confirmed by nuclear magnetic resonance and infrared spectroscopy. In several tests, this chitosan showed low or no antioxidant activity. However, it also showed excellent copper-chelating activity. In vitro, chitosan acted as an inducer mainly of monohydrate CaOx crystal formation, which is more prevalent in patients with urolithiasis. We also observed that chitosan modifies the morphology and size of these crystals, as well as changes the surface charge of the crystals, making them even more positive, which can facilitate the interaction of these crystals with renal cells. Chitosan greatly influences the formation of crystals in vitro, and in vivo analyses should be conducted to assess the risk of using chitosan.
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影响因子：
3.4
作者：
Baldrick, Paul
通讯作者：
Baldrick, Paul
影响因子：
19.6
作者：
FINLAYSON, B
通讯作者：
FINLAYSON, B
DOI：
10.1016/s0731-7085(03)00155-9
发表时间：
2003-08-21
影响因子：
3.4
作者：
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通讯作者：
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影响因子：
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通讯作者：
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Kulaksizoglu, Sevsen;Sofikerim, Mustafa;Cevik, Cemal
通讯作者：
Cevik, Cemal