Both DA1 and DA2 receptor agonists are necessary to inhibit NaKATPase activity in proximal tubules from rat kidney.
Both DA1 and DA2 receptor agonists are necessary to inhibit NaKATPase activity in proximal tubules from rat kidney.
复制标题
DA1 和 DA2 受体激动剂都是抑制大鼠肾近端肾小管 NaKATP 酶活性所必需的。
DOI：
10.1111/j.1748-1716.1988.tb08350.x
复制
发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Anita Aperia
中科院分区：
文献类型：
--
作者：
A. Bertorello;Anita Aperia
多巴胺(DA)抑制大鼠肾近曲小管(PCT)段的NaKATPase活性。1987)。抑制是快速和可逆的。有两种多巴胺受体亚型，DA和DA(KeBabian&Calne 1979)。在先前的研究中，我们无法证明高特异性DA或DA激动剂对PCT片段中的NaKATPase活性有任何抑制作用。最近已经证明，在富含内源性DA的组织中，DA和DA特异性激动剂之间存在协同作用(Waiters等人。1987)。这促使我们研究了DA和DA激动剂对通透性大鼠肾PCT中NaKATPase活性的联合影响。实验选用体重在150-180克之间的雄性SD大鼠。肾灌注和肾小管显微剥离如前所述。
Dopamine (DA) inhibits NaKATPase activity in rat renal proximal convoluted tubules (PCT) segments (Aperia el al. 1987). Inhibition is rapid and reversible. There are two dopamine receptor subtypes, DA, and DA,(Kebabian & Calne 1979). In the previous study we were unable to demonstrate any inhibition of NaKATPase activity in PCT segments incubated with either a highly specific DA, or DA, agonist. It has recently been demonstrated that in tissue abundant with endogenous DA, there is a synergistic interaction between the DA,-and DA,-specific agonists (Waiters et al. 1987). This has prompted us to examine the combined effect of DA, and DA, agonists on NaKATPase activity in permeabilized rat renal PCT. Male Sprague-Dawley rats weighing between 150 and 180 g were used in the experiments. Kidney perfusion and tubule microdissection were performed as described previously in detail
兔子近曲小管中的多巴胺受体。
DOI：
10.1152/ajprenal.1984.247.3.f499
发表时间：
1984
期刊：
The American journal of physiology
影响因子：
--
作者：
Felder,RA;Blecher,M;Calcagno,PL;Jose,PA
通讯作者：
Jose,PA
多巴胺受体调节去神经支配肾脏中的钠排泄。
DOI：
10.1152/ajprenal.1986.250.6.f1033
发表时间：
1986
期刊：
The American journal of physiology
影响因子：
--
作者：
Jose,PA;Felder,RA;Holloway,RR;Eisner,GM
通讯作者：
Eisner,GM