Early neglect and abuse predict diurnal cortisol patterns in adults A study of international adoptees
Early neglect and abuse predict diurnal cortisol patterns in adults A study of international adoptees
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早期忽视和虐待可预测成人的昼夜皮质醇模式 对国际被收养者的研究
DOI：
10.1016/j.psyneuen.2008.11.004
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发表时间：
2009
影响因子：
3.7
通讯作者：
H. Tiemeier
中科院分区：
文献类型：
--
作者：
Esther J. M. Vegt;J. Ende;C. Kirschbaum;F. Verhulst;H. Tiemeier
幼年时期的吸毒和虐待与皮质醇水平的升高和降低有关，也与昼夜皮质醇斜率的改变有关。在本研究中，我们调查了早期虐待-在不同的严重程度-和基础皮质醇分泌的成人收养儿童之间的长期关系。对国际被收养者的样本进行了从童年到成年的跟踪。在儿童时期，养父母在收养之前提供了关于忽视和虐待的信息。成年后，被收养者每天收集四次唾液样本。早期虐待和皮质醇分泌之间的关系进行了研究，主要是在623被收养的多层次分析。被收养者的养父母报告了严重的忽视或虐待，其早晨皮质醇水平低于未被忽视或未被虐待的参与者（各自的估计值（标准误差（SE））和p值：-0.33（0.090），p=0.0002和-0.63（0.20），p=0.002）。相对于未被忽视的被收养者，那些据称经历过严重忽视的被收养者的昼夜斜率也更平坦（估计值（SE）和p值：0.028（0.0088），p=0.002）。相比之下，相对于未受虐待的参与者，报告虐待程度为中度的被收养者的皮质醇水平较高，皮质醇昼夜斜率更陡（各自的估计值（SE）和p值：0.29（0.13），p=0.003和-0.039（0.012），p=0.01）。因此，早期忽视和虐待似乎与皮质醇水平和昼夜斜率有关，即使儿童在早期虐待后在另一个环境中长大。我们的研究表明，早期虐待的严重程度可能与基础皮质醇模式。
Neglect and abuse early in life have been associated with increased and decreased cortisol levels, and also with an altered diurnal cortisol slope. In the present study, we investigated the long-term relationship between early maltreatment – at different levels of severity – and basal cortisol secretion in adults adopted as children. A sample of international adoptees was followed from childhood to adulthood. In childhood, adoptive parents had provided information about neglect and abuse prior to adoption. As adults, adoptees collected saliva samples four times a day. The relationship between early maltreatment and cortisol secretion was examined, primarily with multilevel analyses in 623 adoptees. Morning cortisol levels were lower in adoptees whose adoptive parents had reported severe neglect or abuse than in non-neglected or non-abused participants (respective estimates (standard errors (SEs)) and p-values: −0.33 (0.090), p=0.0002 and −0.63 (0.20), p=0.002). Relative to non-neglected adoptees, those who had allegedly experienced severe neglect also had a flatter diurnal slope (estimate (SE) and p-value: 0.028 (0.0088), p=0.002). In contrast, relative to non-abused participants, adoptees whose reported abuse was moderately severe had high cortisol levels and a steeper cortisol diurnal slope (respective estimates (SEs) and p-values: 0.29 (0.13), p=0.003 and −0.039 (0.012), p=0.01). Thus, early neglect and abuse appear to have associations with cortisol levels and the diurnal slope, even when children are raised in another environment after their early maltreatment. Our study suggests that the severity of the early maltreatment may be related to the basal cortisol pattern.
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可卡因依赖成年人的尿游离皮质醇和童年创伤。
影响因子：
4.8
作者：
Roy,Alec
通讯作者：
Roy,Alec
影响因子：
10.6
作者：
M. D. Bellis;A. Baum;B. Birmaher;M. Keshavan;Clayton H. Eccard;A. Boring;F. Jenkins;N. Ryan
通讯作者：
M. D. Bellis;A. Baum;B. Birmaher;M. Keshavan;Clayton H. Eccard;A. Boring;F. Jenkins;N. Ryan
影响因子：
120.7
作者：
Heim, C;Newport, DJ;Nemeroff, CB
通讯作者：
Nemeroff, CB
影响因子：
5
作者：
Horwitz, AV;Widom, CS;White, HR
通讯作者：
White, HR