Urinary free cortisol and childhood trauma in cocaine dependent adults.

Urinary free cortisol and childhood trauma in cocaine dependent adults.
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可卡因依赖成年人的尿游离皮质醇和童年创伤。

DOI:
10.1016/s0022-3956(02)00002-x
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发表时间:
2002
影响因子:
4.8
通讯作者:
Roy,Alec
Roy,Alec
中科院分区:
医学2区
文献类型:
--
作者:
Roy,Alec

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目的探讨儿童期创伤是否与成年后下丘脑-垂体-肾上腺(HPA)轴功能有关。方法对46例戒断可卡因依赖者进行24 h尿游离皮质醇(UFC)测定和儿童期创伤问卷(CTQ)调查。结果平均UFC输出低于中位数的患者的儿童期性虐待CTQ评分显著高于UFC输出高于中位数的患者。多元回归分析表明,儿童期的情感忽视和性虐待独立与UFC outputs.ConclusionThese横截面数据,在一个样本的中年可卡因依赖患者,建议的可能性,童年创伤可能有影响HPA轴功能,从而易患精神疾病。需要在不同的样本中进行进一步的研究。
ObjectiveTo examine whether childhood trauma may have a relationship to hypothalamic-pituitary-adrenal (HPA) axis function as an adult.MethodsForty-six withdrawn cocaine dependent patients participated in 24-h urine collections for determination of urinary-free cortisol (UFC) and completed the Childhood Trauma Questionnaire (CTQ).ResultsPatients with a mean UFC output below the median had significantly higher CTQ scores for childhood sexual abuse than patients with UFC outputs above the median. Multiple regression analysis showed that both childhood emotional neglect and sexual abuse were independently associated with UFC outputs.ConclusionThese cross sectional data, in a sample of middle-aged cocaine dependent patients, suggest the possibility that childhood trauma may have an effect on HPA axis function and thus predispose to psychiatric disorders. Further studies are needed in different samples.
DOI: 10.1016/0169-328x(93)90189-v
发表时间: 1993-05-01
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影响因子: --
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