Urinary free cortisol and childhood trauma in cocaine dependent adults.
Urinary free cortisol and childhood trauma in cocaine dependent adults.
复制标题
可卡因依赖成年人的尿游离皮质醇和童年创伤。
DOI:
10.1016/s0022-3956(02)00002-x
复制
发表时间:
2002
影响因子:
4.8
通讯作者:
Roy,Alec
中科院分区:
文献类型:
--
作者:
Roy,Alec
ObjectiveTo examine whether childhood trauma may have a relationship to hypothalamic-pituitary-adrenal (HPA) axis function as an adult.MethodsForty-six withdrawn cocaine dependent patients participated in 24-h urine collections for determination of urinary-free cortisol (UFC) and completed the Childhood Trauma Questionnaire (CTQ).ResultsPatients with a mean UFC output below the median had significantly higher CTQ scores for childhood sexual abuse than patients with UFC outputs above the median. Multiple regression analysis showed that both childhood emotional neglect and sexual abuse were independently associated with UFC outputs.ConclusionThese cross sectional data, in a sample of middle-aged cocaine dependent patients, suggest the possibility that childhood trauma may have an effect on HPA axis function and thus predispose to psychiatric disorders. Further studies are needed in different samples.
登录
查看更多内容
DOI:
10.1016/0169-328x(93)90189-v
发表时间:
1993-05-01
期刊:
MOLECULAR BRAIN RESEARCH
影响因子:
--
作者:
PLOTSKY, PM;MEANEY, MJ
通讯作者:
MEANEY, MJ
DOI:
--
发表时间:
1980
期刊:
A M A Journal of Diseases of Children
影响因子:
--
作者:
N. Ellerstein;J. Canavan
通讯作者:
J. Canavan
DOI:
10.1176/ajp.141.5.619
发表时间:
1984
期刊:
The American journal of psychiatry
影响因子:
--
作者:
P. Gold;G. Chrousos;C. Kellner;R. Post;A. Roy;P. Augerinos;Heinrich M. Schulte;E. Oldfield;D. Loriaux
通讯作者:
D. Loriaux
影响因子:
120.7
作者:
Heim, C;Newport, DJ;Nemeroff, CB
通讯作者:
Nemeroff, CB
影响因子:
6.6
作者:
Alec Roy
通讯作者:
Alec Roy