The relationship between abdominal fat and change in left ventricular ejection fraction in cancer patients.
The relationship between abdominal fat and change in left ventricular ejection fraction in cancer patients.
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DOI：
10.1002/osp4.454
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发表时间：
2021-03
影响因子：
2.2
通讯作者：
Hundley WG
中科院分区：
文献类型：
--
作者：
Reding KW;Ghemigian K;Carbone S;D'Agostino R Jr;Jordan JH;Meléndez G;Lamar ZS;Klepin HD;Thomas A;Langford D;Vasu S;Hundley WG
先前的研究已经确定了体重指数（BMI）和腹膜内（IP）脂肪与心力衰竭之间的关系;然而，在接受潜在心脏毒性化疗的癌症患者的先前研究中，BMI升高不一定与心脏功能下降相关。本研究验证了IP脂肪可能与接受潜在心脏毒性化疗的癌症患者的左心室射血分数（LVEF）下降相关的假设。在这项纳入61例癌症患者（23例乳腺癌、32例淋巴瘤和6例肉瘤）的前瞻性研究中，使用无创磁共振成像确定了IP脂肪和其他身体成分评估以及癌症治疗前后LVEF的变化。考虑年龄、基线LVEF和混杂变量后，治疗前至治疗后24个月LVEF变化与IP脂肪呈负相关（r =-0.33; p = 0.02），与皮下（SQ）脂肪测量值呈正相关（r = 0.33; p = 0.01）。这些LVEF变化与BMI无关（r = 0.12; p = 0.37）。在接受潜在心脏毒性化疗的患者中，治疗前IP脂肪与随后的LVEF下降相关。BMI与LVEF下降之间无相关性。这些发现可能与SQ脂肪的潜在保护作用有关。
Prior studies have identified a relationship between body mass index (BMI) and intraperitoneal (IP) fat with heart failure; however, in prior studies of cancer patients receiving potentially cardiotoxic chemotherapy, elevations in BMI have not necessarily been associated with decrements in heart function. This study tested the hypothesis that IP fat may be associated with left ventricular ejection fraction (LVEF) decline among cancer patients receiving potentially cardiotoxic chemotherapy. In this prospective study of 61 cancer patients (23 breast cancer, 32 lymphoma, and 6 sarcoma), IP fat and other assessments of body composition, and changes in LVEF from pre‐ to postcancer treatment using noninvasive magnetic resonance imaging was ascertained. After accounting for age, baseline LVEF, and confounding variables, pre‐ to 24‐month post‐treatment LVEF changes were inversely correlated with IP fat (r = −0.33; p = 0.02) and positively correlated with measures of subcutaneous (SQ) fat (r = 0.33; p = 0.01). These LVEF changes were not correlated with BMI (r = 0.12; p = 0.37). Among patients receiving potentially cardiotoxic chemotherapy, pretreatment IP fat was associated with subsequent declines in LVEF. There was no association between BMI and LVEF decline. These findings may be related to a potential protective effect of SQ fat.
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影响因子：
3.8
作者：
Ballak DB;Stienstra R;Tack CJ;Dinarello CA;van Diepen JA
通讯作者：
van Diepen JA
影响因子：
1.6
作者：
Aslani, A;Smith, RC;Levi, JA
通讯作者：
Levi, JA
影响因子：
45.3
作者：
Cardinale, Daniela;Colombo, Alessandro;Cipolla, Carlo M.
通讯作者：
Cipolla, Carlo M.
DOI：
10.1001/jama.2015.17346
发表时间：
2016-01-05
期刊：
JAMA
影响因子：
--
作者：
Kitzman DW;Brubaker P;Morgan T;Haykowsky M;Hundley G;Kraus WE;Eggebeen J;Nicklas BJ
通讯作者：
Nicklas BJ
影响因子：
7.7
作者：
Goodpaster, BH;Kelley, DE;Thaete, FL
通讯作者：
Thaete, FL