Botanical modulation of menopausal symptoms: mechanisms of action?
Botanical modulation of menopausal symptoms: mechanisms of action?
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DOI：
10.1055/s-0032-1328187
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发表时间：
2013-05
期刊：
影响因子：
2.7
通讯作者：
Bolton JL
中科院分区：
文献类型：
--
作者：
Hajirahimkhan A;Dietz BM;Bolton JL
更年期妇女会有各种各样的症状，包括潮热和盗汗，这些都会影响她们的生活质量。虽然激素疗法（HT）一直是缓解这些症状的首选治疗方法，但HT与乳腺癌风险增加有关，导致许多妇女寻找天然、有效和安全的替代品，如植物补充剂。临床试验数据表明，植物药对缓解绝经期症状有疗效，但一直存在争议，并提出了几种作用机制，包括雌激素、孕激素和血清素能途径。具有潜在雌激素活性的植物提取物包括大豆、红三叶草、葛草、啤酒花、甘草、大黄、山药和蔓越莓。据报道具有孕激素活性的植物有红三叶草、啤酒花、山药和蔓越莓。由于服用抗抑郁药的妇女经常报告潮热和盗汗减少，因此也提出了血清素能机制。黑升麻、葛、卡瓦、甘草和冬葵都有5-HT7配体或抑制5-羟色胺再摄取，因此具有潜在的5-羟色胺能活性。了解这些用于妇女健康的自然疗法的作用机制，可以导致更有效的配方和分离活性成分，这些成分有可能在未来成为有效的药物。
Menopausal women suffer from a variety of symptoms, including hot flashes and night sweats which can affect quality of life. Although hormone therapy (HT) has been the treatment of choice for relieving these symptoms, HT has been associated with increased breast cancer risk leading many women to search for natural, efficacious, and safe alternatives such as botanical supplements. Data from clinical trials suggesting that botanicals have efficacy for menopausal symptom relief, have been controversial and several mechanisms of action have been proposed including estrogenic, progestogenic, and serotonergic pathways. Plant extracts with potential estrogenic activities include soy, red clover, kudzu, hops, licorice, rhubarb, yam, and chasteberry. Botanicals with reported progestogenic activities are red clover, hops, yam, and chasteberry. Serotonergic mechanisms have also been proposed since women taking antidepressants often report reduction in hot flashes and night sweats. Black cohosh, kudzu, kava, licorice, and dong quai all either have reported 5-HT7 ligands or inhibit serotonin re-uptake, therefore have potential serotonergic activities. Understanding the mechanisms of action of these natural remedies used for women’s health, could lead to more efficacious formulations and to the isolation of active components which have the potential of becoming effective medications in the future.
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DOI：
10.1590/s0100-879x2009007500026
发表时间：
2010-02-01
影响因子：
2.3
作者：
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