Estrogen deficiency increases variability of tissue mineral density of alveolar bone surrounding teeth.
Estrogen deficiency increases variability of tissue mineral density of alveolar bone surrounding teeth.
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DOI：
10.1016/j.archoralbio.2010.05.011
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发表时间：
2010-08
影响因子：
3
通讯作者：
Kim, Do-Gyoon
中科院分区：
文献类型：
--
作者：
Ames, Matthew S.;Hong, Semi;Lee, Hye Ri;Fields, Henry W.;Johnston, William M.;Kim, Do-Gyoon
雌激素缺乏会增加骨重建，导致组织矿物质密度(TMD)的变异性增加。由于咀嚼功能的需要，牙齿周围的牙槽骨本质上是一个高度重塑的骨组织区域，其TMD分布高度可变。本研究探讨雌激素缺乏对牙槽骨TMD分布的影响。利用假手术(Sham)和去卵巢(OVX)大鼠下颌骨切片的三维CT图像，分离出感兴趣的牙槽骨区(AB)和对照骨区(CB)。根据相当于TMD值的灰度直方图，计算平均(Mean)、标准差(SD)和变异系数(COV=SD/Mean)。还获得了第五和第95个百分位数的灰度值(分别为Low5和High5)。计算AB区和CB区灰度参数差值百分数(%)的绝对值。假手术组和去卵巢组AB区SD和COV均显著高于CB区(p<；0.001)。与假手术组相比，卵巢切除组SD的平均差值略高(p<；0.073)，COV和Low5的差值显著增加(p<；0.04)。OVX组AB中观察到的矿化变异性较高，表明雌激素缺乏放大了由于咀嚼而已经存在的AB的活跃的骨重建。这些发现提供了一个洞察力，即雌激素缺乏导致的TMD的变异性增加可能会损害承载牙齿的牙槽骨的机械稳定性。
Estrogen deficiency increases bone remodeling leading to increased variability of tissue mineral density (TMD). Due to the functional demands of mastication, alveolar bone around teeth is inherently a highly remodeled region of bone tissue with a highly variable distribution of TMD. This study investigated the effect of estrogen deficiency on the TMD distribution of alveolar bone. Using three-dimensional micro-computed tomography images of sham surgery (Sham) and ovariectomized (OVX) rat mandible sections, alveolar bone region (AB) and control bone region (CB) of interest were isolated. Based on histograms of gray levels equivalent to TMD values, mean (Mean), standard deviation (SD) and coefficient of variation (COV=SD/Mean) were computed. Fifth and 95th percentile gray level values were also obtained (Low5 and High5, respectively). Absolute value of percentage (%) differences of the gray level parameters between AB and CB regions were computed. Both SD and COV were significantly higher in AB region than those in CB region for all specimens of both Sham and OVX groups (p<0.001). The mean values of % differences for SD were moderately higher (p<0.073) and those for COV and Low5 were significantly higher for the OVX group than for the Sham group (p<0.04). Higher variability of mineralization observed in AB of OVX group indicates that estrogen deficiency amplifies the active bone remodeling of AB already present due to mastication. These findings provide an insight that the increased variability of TMD induced by estrogen deficiency may compromise the mechanical stability of the tooth-bearing alveolar bone.
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DOI：
10.1046/j.0301-5661.2003.00110.x
发表时间：
2004-02-01
影响因子：
2.3
作者：
McGrath, C;Bedi, R
通讯作者：
Bedi, R
影响因子：
2
作者：
Arslan, Seher Guenduez;Arslan, Hueseyin;Hamamci, Orhan
通讯作者：
Hamamci, Orhan
影响因子：
4
作者：
Boivin, G.;Farlay, D.;Delmas, P. D.
通讯作者：
Delmas, P. D.
影响因子：
7.6
作者：
Huja, S. S.;Fernandez, S. A.;Gulati, P.
通讯作者：
Gulati, P.
影响因子：
4.1
作者：
Follet, H;Boivin, G;Meunier, PJ
通讯作者：
Meunier, PJ