Vision-Related Quality of Life Among Healthy, Preperimetric Glaucoma, and Perimetric Glaucoma Patients.
Vision-Related Quality of Life Among Healthy, Preperimetric Glaucoma, and Perimetric Glaucoma Patients.
复制标题
DOI：
10.1016/j.ajo.2022.12.018
复制
发表时间：
2023-04
影响因子：
4.2
通讯作者：
Weinreb, Robert N.
中科院分区：
文献类型：
--
作者：
Nishida, Takashi;Moghimi, Sasan;Yamane, Maya L. M.;Wu, Jo-Hsuan;Mohammadzadeh, Vahid;Kamalipour, Alireza;Mahmoudinezhad, Golnoush;Liebmann, Jeffrey M.;Fazio, Massimo A.;Girkin, Christopher A.;Zangwill, Linda M.;Weinreb, Robert N.
[目的]探讨健康受试者及周围性青光眼患者的视觉相关生活质量与中央视野和黄斑神经节细胞复合体(GCC)厚度的关系。横断面研究。共有39名健康人、34名围产期青光眼患者和145名周围性青光眼患者完成了25项国家眼科研究所视觉功能问卷(NEI-VFQ)。采用线性混合效应模型研究双眼10~(-2)视野平均敏感度测量的青光眼分期和GCC厚度与Rasch校正的NEI-VFQ评分之间的关系。共纳入218名参与者的436只眼(平均年龄=67.2[95%可信区间65.1~69.2]岁)。根据NEI-VFQ Rasch校准评分计算的VRQOL在周围性青光眼患者中最差(50.7[95%CI，47.2~54.2])，其次是周围性青光眼患者(41.2[95%CI，34.5~47.9])和健康对照组(29.3[95%CI，24.0~34.7]。较差的VRQOL与较差的双眼10-2VFMS(−3.4[95%CI，−5.0至−1.9]db/1分；P=0.0 0 1；调整后R2=0.2 7)中度相关，但与较好眼的GCC较瘦(−0.1[95%CI，−0.2至0.1]μm每1分；P=.0485；调整后R2=0.17)无关。这些发现表明，周围期和周围期青光眼患者的VRQOL比健康眼更差。与黄斑厚度测量相比，中心视野与VRQOL的相关性更强，可能更有助于识别需要干预的患者。在这项对218名参与者(39名健康对照、34名围产期青光眼和145名周围性青光眼患者)的横断面研究中，周围性青光眼患者的视力相关生活质量较差，其次是围产期青光眼患者和健康对照组。与神经节细胞复合体厚度相比，双眼10-2视野平均敏感度与视觉相关生活质量的相关性更强。
To investigate the association of vision-related quality of life (VRQOL) with the central visual field and macular ganglion cell complex (GCC) thickness in healthy participants, and patients with preperimetric and perimetric glaucoma. Cross-sectional study. A total of 39 healthy, 34 preperimetric glaucoma, and 145 perimetric glaucoma patients completed the 25-item National Eye Institute Visual Function Questionnaire (NEI-VFQ). A linear mixed effect models was used to investigate the association between the glaucoma stage as measured by binocular 10–2 visual field mean sensitivity (VFMS) and GCC thickness with the Rasch-calibrated NEI-VFQ score. A total of 436 eyes from 218 participants (mean age = 67.2 [95% CI, 65.1 to 69.2] years) were enrolled. VRQOL calculated by the NEI-VFQ Rasch-calibrated score was worst for patients with perimetric glaucoma (50.7 [95%CI, 47.2 to 54.2]), followed by patients with preperimetric glaucoma (41.2 [95%CI, 34.5 to 47.9]) and healthy controls (29.3 [95%CI, 24.0 to 34.7]. Worse VRQOL had a moderate association with a worse global binocular 10–2 VFMS (−3.4 [95%CI, −5.0 to −1.9] dB per 1 score; P=<.001; adjusted-R2 = 0.27), but not with a thinner global GCC in the better eye (−0.1 [95%CI, −0.2 to 0.1] μm per 1 score; P=.0485; adjusted-R2 = 0.17). These findings suggest that patients with perimetric and preperimetric glaucoma have worse VRQOL than healthy eyes. As compared to macular thickness measurements, the central visual field is more strongly associated with VRQOL and may better help to identify patients in need of intervention. In this cross-sectional study of 218 participants (39 healthy controls, 34 preperimetric glaucoma, and 145 perimetric glaucoma patients), vision-related quality of life was worse for patients with perimetric glaucoma, followed by patients with preperimetric glaucoma and healthy controls. Binocular 10–2 visual field mean sensitivities were more strongly associated with vision-related quality of life than ganglion cell complex thickness.
登录
查看更多内容
影响因子：
17.8
作者：
De Moraes CG;Liebmann JM;Levin LA
通讯作者：
Levin LA
影响因子：
--
作者：
Globe, DR;Varma, R;Azen, SP
通讯作者：
Azen, SP
影响因子：
13.7
作者：
Medeiros, Felipe A.;Gracitelli, Carolina P. B.;Boer, Erwin R.;Weinreb, Robert N.;Zangwill, Linda M.;Rosen, Peter N.
通讯作者：
Rosen, Peter N.
影响因子：
17.8
作者：
Hood DC;Raza AS;de Moraes CG;Liebmann JM;Ritch R
通讯作者：
Ritch R
影响因子：
4.2
作者：
Abe, Ricardo Y.;Gracitelli, Carolina P. B.;Medeiros, Felipe A.
通讯作者：
Medeiros, Felipe A.