A kind of biomolecular probe sensor based on TFBG surface plasma resonance
A kind of biomolecular probe sensor based on TFBG surface plasma resonance
复制标题
一种基于TFBG表面等离子体共振的生物分子探针传感器
DOI：
10.1007/s13320-015-0232-5
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发表时间：
2015
期刊：
影响因子：
4.4
通讯作者：
Jianqiang Lin
中科院分区：
文献类型：
--
作者：
Mengwei Xue;Q. Jiang;Chengjia Zhang;Jianqiang Lin
报道了基于倾斜光纤布拉格光栅（TFBG）表面等离子体共振（SPR）技术的生物分子探针传感器的应用，该传感器通过在活性金膜外沉积敏感的生物膜来识别特定分子的特异性。采用自组装的方法制备固定化敏感生物膜，使其在实验中达到最佳效果。为了说明DNA分子的特异性识别，TFBG-SPR生物传感器暴露于浓度分别为0.1 mmol/L和0.05 mmol/L的互补DNA溶液。TFBG-SPR生物传感器的共振波长逐渐增加，表明与互补DNA分子的杂交改变了金层附近的有效折射率。实验结果进一步验证了基于TFBG表面等离子体共振的生物分子探针传感器用于检测特定分子的可行性。
This paper reports the application of the biomolecular probe sensor based on the tilted fiber Bragg grating (TFBG) surface plasma resonance (SPR) which can recognize the specificity of the specific molecule by depositing sensitive biological membrane outside the active golden layer. The method of self-assembly was used to make the fixed sensitive biological membrane to achieve the best effect in the experiment. To illustrate the specific recognition of the DNA molecule, the TFBG-SPR biosensor was exposed to complementary DNA solutions with the concentration of 0.1 mmol/L and 0.05 mmol/L, respectively. The resonance wavelength of the TFBG-SPR biosensor increased gradually, indicating that the hybridization with the complementary DNA molecules changed the effective refractive index in the vicinity of the golden layer. Furthermore, the results illustrated the feasibility of the biomolecular probe sensor based on the TFBG surface plasma resonance for detecting the specific molecule.
影响因子：
12.6
作者：
Shevchenko, Yanina;Camci-Unal, Gulden;Cuttica, Davide E.;Dokmeci, Mehmet R.;Albert, Jacques;Khademhosseini, Ali
通讯作者：
Khademhosseini, Ali