Trabecular and cortical microarchitecture in postmenopausal HIV-infected women.
Trabecular and cortical microarchitecture in postmenopausal HIV-infected women.
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DOI：
10.1007/s00223-013-9716-8
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发表时间：
2013-06
影响因子：
4.2
通讯作者：
Shane, Elizabeth
中科院分区：
文献类型：
--
作者：
Yin, Michael T.;Shu, Aimee;Zhang, Chiyuan A.;Boutroy, Stephanie;McMahon, Donald J.;Ferris, David C.;Colon, Ivelisse;Shane, Elizabeth
To assess the effects of HIV infection and antiretroviral therapy (ART) on trabecular and cortical microarchitecture in postmenopausal minority women. A subgroup of 106 (46 HIV-infected, 60 uninfected) postmenopausal Hispanic and African American women from an established cohort had areal bone mineral density (aBMD) measured by dual-energy x-ray absorptiometry, and trabecular and cortical volumetric BMD (vBMD) and microarchitecture measured by high-resolution peripheral quantitative computed tomography (HRpQCT) at the radius and tibia. HIV-infected women were slightly younger (58±1 versus 61±1 yrs, p=0.08), and had lower body mass index (BMI, 28±1 versus 32±1 kg/m2, p<0.01). BMI-adjusted aBMD Z scores were lower in HIV-infected women at the lumbar spine, total hip and ultradistal radius. Serum N-telopeptide and C-telopeptide levels were also higher in HIV-infected women. Trabecular and cortical vBMD were similar at the radius, but cortical area (105.5±2.4 versus 120.6±2.0mm2, p<0.01) and thickness (956±33 versus 1075±28 m, p<0.01) at the tibia were approximately 11–12% lower in HIV-infected women. Differences remained significant after adjusting for age, BMI and race/ethnicity. In contrast, cortical porosity was similar in both groups. Although HIV-infected postmenopausal women had lower aBMD at the spine, total hip and ultradistal radius and higher levels of bone resorption markers, the only differences detected by HRpQCT were lower cortical thickness and area at the tibia.
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影响因子：
4
作者：
Melton, L. J., III;Christen, D.;Riggs, B. L.;Achenbach, S. J.;Mueller, R.;van Lenthe, G. H.;Amin, S.;Atkinson, E. J.;Khosla, S.
通讯作者：
Khosla, S.
影响因子：
6.2
作者：
Melton, L. Joseph, III;Riggs, B. Lawrence;Khosla, Sundeep
通讯作者：
Khosla, Sundeep
影响因子：
6.2
作者：
Boutroy, Stephanie;Van Rietbergen, Bert;Delmas, Pierre D.
通讯作者：
Delmas, Pierre D.
影响因子：
6.2
作者：
Nishiyama, Kyle K.;Macdonald, Heather M.;Boyd, Steven K.
通讯作者：
Boyd, Steven K.
影响因子：
5.8
作者：
Burghardt, Andrew J.;Issever, Ahi S.;Link, Thomas M.
通讯作者：
Link, Thomas M.