Defining recurrent implantation failure: a profusion of confusion or simply an illusion?

Defining recurrent implantation failure: a profusion of confusion or simply an illusion?
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DOI:
10.1016/j.fertnstert.2021.10.023
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发表时间:
2021-12
影响因子:
6.7
通讯作者:
Young SL
Young SL
中科院分区:
医学2区
文献类型:
--
作者:
Garneau AS;Young SL

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复发性着床失败(RIF)是一种定义不清的临床情况,其特征是多次胚胎移植后未能妊娠。植入失败的原因和定义各不相同,对研究设计以及结果的解释和应用造成了限制。最近的研究提出了一种新的,个性化的方法来定义RIF。在这里,我们将回顾植入生理学和植入率,失败和RIF的定义。目前对监管和体制框架的定义差别很大。未来定义RIF的方法可能会根据是否存在植入失败的风险因素(如整倍性)进行个性化。
Recurrent implantation failure (RIF) is a poorly defined clinical scenario marked by failure to achieve pregnancy after multiple embryo transfers. The causes and definitions of implantation failure are heterogenous, posing limitations on study design as well as the interpretation and application of findings. Recent studies suggest a novel, personalized approach to defining RIF. Here, we will review implantation physiology and the definitions of implantation rate, failure, and RIF. Current definitions of RIF vary greatly. Future approaches to defining RIF may be personalized based on the presence or absence of risk factors for implantation failure, such as euploidy.
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