HLA-C levels impact natural killer cell subset distribution and function.
HLA-C levels impact natural killer cell subset distribution and function.
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DOI：
10.1016/j.humimm.2016.08.004
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发表时间：
2016-12
期刊：
影响因子：
2.7
通讯作者：
Alter G
中科院分区：
文献类型：
--
作者：
Sips M;Liu Q;Draghi M;Ghebremichael M;Berger CT;Suscovich TJ;Sun Y;Walker BD;Carrington M;Altfeld M;Brouckaert P;De Jager PL;Alter G
HLA-C表达的差异与HIV病毒载量设定点和向AIDS进展较慢呈负相关，与增强的细胞毒性T细胞免疫有关。然而，除了T细胞之外，HLA-C作为自然杀伤（NK）细胞杀伤免疫球蛋白样受体（KIR）的主要配体。因此，我们推测HLA-C表达水平也可能影响NK活性，从而调节HIV抗病毒控制。对新鲜分离的PBMC进行表型和功能分析。HLA-C表达与NK细胞亚群分布和许可的变化有关，特别是在HLA-C1/C1，KIR 2DL 3 + 2DL 2-个体中。此外，高水平的HLA-C与无反应性CD 56阴性NK细胞的频率降低和KIR 2DL 1/2/3+ NK细胞的频率降低相关，表明在没有疾病的情况下HLA-C诱导对NK细胞发育的影响。在HIV感染中，表达较高水平的HLA-C的几种自发控制者表现出响应于靶细胞的稳健的NK-IFN-γ分泌，突出了第二种疾病诱导的许可表型。因此，这项人群研究指出了HLA-C水平在NK细胞教育和发育中的潜在作用。
Differences in HLA-C expression are inversely correlated with HIV viral load set-point and slower progression to AIDS, linked to enhanced cytotoxic T cell immunity. Yet, beyond T cells, HLA-C serves as a dominant ligand for natural killer (NK) cell killer immunoglobulin-like receptors (KIR). Thus, we speculated that HLA-C expression levels may also impact NK activity, thereby modulating HIV antiviral control. Phenotypic and functional profiling was performed on freshly isolated PBMCs. HLA-C expression was linked to changes in NK subset distribution and licensing, particularly in HLA-C1/C1, KIR2DL3+2DL2-individuals. Moreover, high levels of HLA-C, were associated with reduced frequencies of anergic CD56neg NKs and lower frequencies of KIR2DL1/2/3+ NK cells, pointing to an HLA-C induced influence on the NK cell development in the absence of disease. In HIV infection, several spontaneous controllers, that expressed higher levels of HLA-C demonstrated robust NK-IFN-γ secretion in response to target cells, highlighting a second disease induced licensing phenotype. Thus this population study points to a potential role for HLA-C levels both in NK cell education and development.
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HLA-C组单倍型确定原发性HIV-1感染中KIR2DL1-3⁺NK细胞的频率和功能的增加。
影响因子：
5.4
作者：
Koerner, Christian;Granoff, Mitchell E.;Amero, Molly A.;Sirignano, Michael N.;Vaidya, Sagar A.;Jost, Stephanie;Allen, Todd M.;Rosenberg, Eric S.;Altfeld, Marcus
通讯作者：
Altfeld, Marcus
影响因子：
20.3
作者：
Gumá, M;Angulo, A;López-Botet, M
通讯作者：
López-Botet, M
影响因子：
30.8
作者：
Martin, Maureen P.;Qi, Ying;Carrington, Mary
通讯作者：
Carrington, Mary
DOI：
10.1073/pnas.90.24.12000
发表时间：
1993-12-15
影响因子：
11.1
作者：
COLONNA, M;BORSELLINO, G;STROMINGER, JL
通讯作者：
STROMINGER, JL
影响因子：
30.3
作者：
Apps R;Del Prete GQ;Chatterjee P;Lara A;Brumme ZL;Brockman MA;Neil S;Pickering S;Schneider DK;Piechocka-Trocha A;Walker BD;Thomas R;Shaw GM;Hahn BH;Keele BF;Lifson JD;Carrington M
通讯作者：
Carrington M