Sustained interactions between T cell receptors and antigens promote the differentiation of CD4⁺ memory T cells.
Sustained interactions between T cell receptors and antigens promote the differentiation of CD4⁺ memory T cells.
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DOI：
10.1016/j.immuni.2013.08.033
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发表时间：
2013-09-19
期刊：
影响因子：
32.4
通讯作者：
Williams MA
中科院分区：
文献类型：
--
作者：
Kim C;Wilson T;Fischer KF;Williams MA
在 CD4+ T 细胞激活过程中，T 细胞受体 (TCR) 信号影响 T 细胞的命运，包括招募、扩增、分化、运输和存活。为了确定 TCR 信号对激活的 CD4+ T 细胞成为终末期效应细胞或长寿命记忆 T 辅助细胞 1 (Th1) 细胞的命运决定的影响，我们设计了一种基于深度测序的方法，使我们能够跟踪急性感染后 TCR 库的演变。效应Th1细胞向记忆库的转变与库多样性的显着下降相关，并且主要组织相容性复合物（MHC）II类四聚体解离率（而不是四聚体亲合力）是记忆阶段个体克隆T细胞群代表的关键预测因素。我们得出的结论是，在辅助性 T 细胞 1 (Th1) 对急性感染的反应过程中与抗原的稳定和持续的相互作用是促进 Th1 记忆细胞分化的决定性因素。
During CD4+ T cell activation, T cell receptor (TCR) signals impact T cell fate, including recruitment, expansion, differentiation, trafficking and survival. To determine the impact of TCR signals on the fate decision of activated CD4+ T cells to become end-stage effector or long-lived memory T-helper 1 (Th1) cells, we devised a deep sequencing-based approach that allowed us to track the evolution of TCR repertoires following acute infection. The transition of effector Th1 cells into the memory pool was associated with a significant decrease in repertoire diversity, and major histocompatibility complex (MHC) Class II tetramer off-rate, but not tetramer avidity, was a key predictive factor in the representation of individual clonal T cell populations at the memory stage. We conclude that stable and sustained interactions with antigen during the development of T-helper 1 (Th1) responses to acute infection are a determinative factor in promoting the differentiation of Th1 memory cells.
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