The initial interplay between HIV and mucosal innate immunity.
The initial interplay between HIV and mucosal innate immunity.
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DOI：
10.3389/fimmu.2023.1104423
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发表时间：
2023
影响因子：
7.3
通讯作者：
Criscuolo E
中科院分区：
文献类型：
--
作者：
Caputo V;Libera M;Sisti S;Giuliani B;Diotti RA;Criscuolo E
人类免疫缺陷病毒（HIV）仍然是全球主要的健康问题之一，尽管在研究HIV感染的发病机制方面已经付出了巨大的努力，但仍有几个方面需要澄清，包括先天免疫如何在不同的解剖区室中起作用。鉴于艾滋病毒作为一种性传播疾病的性质，需要特别注意的一个方面是粘膜先天免疫反应。鉴于这种情况，我们将注意力集中在HIV和粘膜先天反应之间的相互作用上：不同的粘膜作为一个物理屏障，其完整性可以被感染所破坏，病毒-细胞相互作用诱导先天免疫反应。此外，我们探讨了粘膜微生物群在促进或预防HIV感染中的作用，并强调了其变化如何影响几种机会性感染的发展。尽管最近取得了进展，但粘膜先天免疫反应和微生物群的适当表征仍然缺失，需要进一步研究以了解它们如何有助于有效疫苗的制定。
Human Immunodeficiency Virus (HIV) is still one of the major global health issues, and despite significant efforts that have been put into studying the pathogenesis of HIV infection, several aspects need to be clarified, including how innate immunity acts in different anatomical compartments. Given the nature of HIV as a sexually transmitted disease, one of the aspects that demands particular attention is the mucosal innate immune response. Given this scenario, we focused our attention on the interplay between HIV and mucosal innate response: the different mucosae act as a physical barrier, whose integrity can be compromised by the infection, and the virus-cell interaction induces the innate immune response. In addition, we explored the role of the mucosal microbiota in facilitating or preventing HIV infection and highlighted how its changes could influence the development of several opportunistic infections. Although recent progress, a proper characterization of mucosal innate immune response and microbiota is still missing, and further studies are needed to understand how they can be helpful for the formulation of an effective vaccine.
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影响因子：
4.6
作者：
Arrildt, Kathryn Twigg;Joseph, Sarah Beth;Swanstrom, Ronald
通讯作者：
Swanstrom, Ronald
补体的艾滋病毒调节涉及宫颈粘膜组织感染的途径：转录组和蛋白质组学研究。
影响因子：
7.3
作者：
Svanberg C;Ellegård R;Crisci E;Khalid M;Borendal Wodlin N;Svenvik M;Nyström S;Birse K;Burgener A;Shankar EM;Larsson M
通讯作者：
Larsson M
影响因子：
15.5
作者：
Borgognone, Alessandra;Noguera-Julian, Marc;Oriol, Bruna;Noel-Romas, Laura;Ruiz-Riol, Marta;Guillen, Yolanda;Parera, Mariona;Casadella, Maria;Duran, Clara;Puertas, Maria C.;Catala-Moll, Francesc;De Leon, Marlon;Knodel, Samantha;Birse, Kenzie;Manzardo, Christian;Miro, Jose M.;Clotet, Bonaventura;Martinez-Picado, Javier;Molto, Jose;Mothe, Beatriz;Burgener, Adam;Brander, Christian;Paredes, Roger
通讯作者：
Paredes, Roger
影响因子：
56.3
作者：
Boily, Marie-Claude;Baggaley, Rebecca F.;Wang, Lei;Masse, Benoit;White, Richard G.;Hayes, Richard J.;Alary, Michel
通讯作者：
Alary, Michel
影响因子：
82.9
作者：
Bomsel, M
通讯作者：
Bomsel, M