Haversian Remodeling in Guided Bone Regeneration with Calcium Alginate Film in Circular Bone Defect Model of Rabbit
Haversian Remodeling in Guided Bone Regeneration with Calcium Alginate Film in Circular Bone Defect Model of Rabbit
复制标题
海藻酸钙膜引导兔圆形骨缺损模型骨再生的哈弗重塑
DOI：
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发表时间：
2007
期刊：
影响因子：
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通讯作者：
Yan Dong
中科院分区：
文献类型：
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作者：
Hong He;Jian;Jiejun Shi;Feiyun Ping;Guanfu Chen;Yan Dong
本研究的目的是通过研究海藻酸钙膜的哈弗斯改建，探讨生物可吸收海藻酸钙膜在引导骨再生中的作用。在35只兔下颌角造成直径为5 mm的圆形骨缺损。分别用海藻酸钙膜(CAF)和胶原膜(CM)覆盖缺损区作为实验组和对照组。术后1、2、4、6、8周分别进行大体、组织学和免疫组织化学检查，分析愈合情况。实验组出现更多、更早的哈弗氏改建和骨诱导因子，导致骨再生较好。对照组巨噬细胞较多，哈弗氏重塑较少且较晚，吸收较慢，早期收集的骨诱导因子较少。海藻酸钙膜是一种相对便宜的材料，在骨再生、哈弗斯改建和骨诱导因子的含量方面比胶原膜有更好的效果。
The objective of this study is to investigate the effect of bioabsorbable Calcium alginate film in guided bone regeneration by the study of Haversian remodeling. Circular bone defects of 5 mm diameter were created in the corners of mandibles in 35 rabbits. The defects were covered with calcium alginate film (CAF) served as the experimental group, or collagen membrane (CM) as the control group, respectively. Healing condition was analyzed with gross, histological and immunohistochemical studies after 1, 2, 4, 6 and 8 weeks. The experimental group appeared more and earlier Haversian remodeling and osteoinductive factors leading to better bone regeneration. The control group showed more macrophages, less and later Haversian remodeling, absorbled slowly, while collected fewer osteoinductive factors in the early stage. Calcium alginate film, which is a relatively cheaper material, provides better effect than the collagen membrane in bone regeneration, Haversian remodeling and quantity of osteoinductive factors.
影响因子：
4.2
作者：
Lee, JY;Peng, HR;Huard, J
通讯作者：
Huard, J
影响因子：
4.2
作者：
L. Bonewald;G. Mundy
通讯作者：
L. Bonewald;G. Mundy