Are All Anxieties Created Equal? Stress-related Networks and Anxiety Phenotypes in Old Age.
Are All Anxieties Created Equal? Stress-related Networks and Anxiety Phenotypes in Old Age.
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所有的宗教都是平等的吗？压力相关网络和老年焦虑表型。
DOI：
10.1016/j.jagp.2021.12.007
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发表时间：
2022-07
影响因子：
7.2
通讯作者：
Andreescu, Carmen
中科院分区：
文献类型：
--
作者：
Kolobaric, Antonija;Karim, Helmet T.;Banihashemi, Layla;Mizuno, Akiko;Aizenstein, Howard J.;Andreescu, Carmen
由于慢性症状，如严重的担忧和/或反刍，压力相关网络的失调是将晚年焦虑与认知能力下降和心血管负担增加联系起来的假定途径之一。严重忧虑或沉思等症状对标准治疗反应不佳，并导致老年人与焦虑相关的发病率。我们评估了是否有任何锚定在压力相关兴趣区域（roi）的神经网络与不同的焦虑表型（担忧、反刍和全局焦虑）相关。我们招募了年龄在50岁以上、焦虑程度不同的老年参与者（N=91）进行静息状态功能磁共振成像。我们计算了每个ROI的基于种子的连通性：终纹床核（BNST）、下丘脑室旁核（PVN）、链核和杏仁核。我们将连通性分析限制在每个基于种子roi的网络的提取区域，该网络基于1000个参与者的规范网络（Neurosynth）。运用连通性和临床因素，拟合交叉验证弹性网络模型，预测宾夕法尼亚州立大学焦虑问卷、反刍子量表、汉密尔顿焦虑评定量表和感知压力量表的得分。我们确定了几种不同的连接模式，可以预测焦虑表型的严重程度。更大的担忧与更大的pvn -亚属前扣带皮层、海马旁（PHC）以及嗅觉和杏仁核-PHC连接有关。更大的整体焦虑与下杏仁核-颞上回连通性有关。更大的感知压力与下杏仁核-下颞回和杏仁核-梭状回的连通性有关。我们的研究表明，不同的晚年焦虑表型（担忧、全局焦虑、反刍）可能与压力和情绪调节相关的不同功能连接有关。这可能有助于制定未来有针对性的干预措施。
The dysregulation of stress-related networks due to chronic symptoms such as severe worry and/or rumination is one of the putative pathways linking anxiety in late-life with cognitive decline and increased cardiovascular burden. Symptoms such as severe worry or rumination respond poorly to standard treatment and drive the morbidity associated with anxiety in older adults. We assessed if any of the neural networks anchored in the stressrelated regions of interest (ROIs) are associated with distinct anxiety phenotypes (worry, rumination and global anxiety). We recruited older participants (over 50 years of age) with varying levels of worry (N=91) to undergo resting state fMRI. We computed seed-based connectivity for each ROI: the bed nucleus of the stria terminalis (BNST), the paraventricular nucleus of the hypothalamus (PVN), habenula, and amygdala. We limited our connectivity analyses to extracted regions for each seeded ROI-based network based on their canonical networks in 1000 participants (Neurosynth). Using connectivity and clinical factors, we fit cross-validated elastic net models to predict scores on Penn State Worry Questionnaire, Rumination Subscale Questionnaire, Hamilton Anxiety Rating Scale, and Perceived Stress Scale. We identified several distinct connectivity patterns that predict anxiety phenotypes’ severity. Greater worry was associated with greater PVN-subgenual anterior cingulate cortex, parahippocampal (PHC), and olfactory and amygdala-PHC connectivity. Greater global anxiety was associated with lower amygdala-superior temporal gyrus connectivity. Greater perceived stress was associated with lower amygdala-inferior temporal gyrus and amygdala-fusiform gyrus connectivity. Our study suggests that various late-life anxiety phenotypes (worry, global anxiety, rumination) may be associated with varying functional connectivity related to stress and emotion regulation. This may aid in the development of future targeted interventions.
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忧虑之中：晚年广泛性焦虑症忧虑诱导和重新评估期间脑血流量的变化。
影响因子：
6.8
作者：
Karim HT;Tudorascu DL;Butters MA;Walker S;Aizenstein HJ;Andreescu C
通讯作者：
Andreescu C
影响因子：
11.3
作者：
Andreescu C;Mennin D;Tudorascu D;Sheu LK;Walker S;Banihashemi L;Aizenstein H
通讯作者：
Aizenstein H
影响因子：
12.8
作者：
Babaev O;Piletti Chatain C;Krueger-Burg D
通讯作者：
Krueger-Burg D
在大鼠和人类中持续的恐惧：恐惧与焦虑中的杏仁核的作用。
DOI：
10.1038/npp.2009.109
发表时间：
2010-01
期刊：
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
影响因子：
--
作者：
通讯作者：
--
影响因子：
2.8
作者：
Bagby, RM;Rector, NA;McBride, C
通讯作者：
McBride, C