Mutations of Cx43 that affect B cell spreading in response to BCR signaling.
Mutations of Cx43 that affect B cell spreading in response to BCR signaling.
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DOI：
10.1242/bio.20147328
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发表时间：
2014-03-15
期刊：
影响因子：
2.4
通讯作者：
Matsuuchi L
中科院分区：
文献类型：
--
作者：
Falk L;Dang-Lawson M;Vega JL;Pournia F;Choi K;Jang C;Naus CC;Matsuuchi L
The gap junction (GJ) protein connexin 43 (Cx43) is both necessary and sufficient for B cell receptor (BCR)-mediated cell spreading. To address how Cx43 mediates this effect, we blocked its function genetically, by expressing mutants of Cx43, and pharmacologically, by using chemical inhibitors. While various point mutations of Cx43 inhibited B cell spreading, treatment with channel blocking drugs did not, suggesting that this response was independent of channel function. The critical region of Cx43 appears to be the cytoplasmic carboxyl-terminal (CT) domain, which has previously been shown to be important for B cell spreading. Consistent with this, mutations of either tyrosine 247 or 265 found in the CT were sufficient to inhibit spreading. Thus Cx43 may influence B cell spreading by mechanisms requiring protein binding to, or modification of, these sites in the CT tail.
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影响因子：
4
作者：
Good, Miranda E.;Nelson, Tasha K.;Burt, Janis M.
通讯作者：
Burt, Janis M.
DOI：
10.1073/pnas.90.18.8392
发表时间：
1993-09-15
影响因子：
11.1
作者：
PEAR, WS;NOLAN, GP;BALTIMORE, D
通讯作者：
BALTIMORE, D
影响因子：
4.4
作者：
Jang, Caren;Machtaler, Steven;Matsuuchi, Linda
通讯作者：
Matsuuchi, Linda
DOI：
10.1038/nri2938
发表时间：
2011-03
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
通讯作者：
--
影响因子：
6.6
作者：
Orellana JA;Sáez PJ;Shoji KF;Schalper KA;Palacios-Prado N;Velarde V;Giaume C;Bennett MV;Sáez JC
通讯作者：
Sáez JC