Decline in visual attention and spatial memory in aged rats
Decline in visual attention and spatial memory in aged rats
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老年大鼠视觉注意力和空间记忆下降
DOI：
10.1016/s0197-4580(99)00098-6
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发表时间：
1999
影响因子：
4.2
通讯作者：
A. Björklund
中科院分区：
文献类型：
--
作者：
J. Muir;W. Fischer;A. Björklund
本研究是一个纵向研究的年龄相关的变化表现的5选择系列反应时任务，测试的视觉注意。在获得任务后，在两个场合测试动物执行5选择任务的能力。在测试1中（年轻：7个月;年龄：13-14个月），未发现与年龄相关的基线表现影响。然而，增加任务的注意力负荷显示老年组动物的选择准确性受损。在测试2中（年轻：10-11个月;年龄23-24个月），与年轻组相比，老年组的动物在任务的基线时间表上显著受损。降低注意负荷可以改善老年动物在任务准确性方面的缺陷。本研究的结果表明，在注意力功能的赤字作为一个结果的老化过程中，观察到的基底皮层胆碱能系统的病变后，显着相似。
The present study was a longitudinal study of age-related changes in performance of the 5-choice serial reaction time task, a test of visual attention. Following acquisition of the task, animals were tested on two occasions on their ability to perform the 5-choice task. In Test 1 (Young: 7 months; Aged: 13–14 months) no age-related effects on baseline performance were revealed. However, increasing the attentional load of the task revealed an impairment in choice accuracy by animals of the Aged group. In Test 2 (Young: 10–11 months; Aged 23–24 months), animals of the Aged group were significantly impaired on the baseline schedule of the task compared to the Young group. The deficit in accuracy on the task could be improved in the Aged animals by decreasing the attentional load. The results of the present study suggest a deficit in attentional function as a result of the aging process, markedly similar to that observed following lesions of the basalo-cortical cholinergic system.
基底前脑神经元和记忆：对鹅膏酯和使君子酯的不同易感性的生化、组织学和行为研究。
影响因子：
1.9
作者：
Wenk,GL;Harrington,CA;Tucker,DA;Rance,NE;Walker,LC
通讯作者：
Walker,LC
苯二氮卓受体反向激动剂和尼古丁对衰老大鼠行为警觉性的影响。
DOI：
10.1093/gerona/51a.3.b225
发表时间：
1996
期刊：
The journals of gerontology. Series A, Biological sciences and medical sciences
影响因子：
--
作者：
Turchi,J;Holley,LA;Sarter,M
通讯作者：
Sarter,M