Risk factors for HPV infection and high-grade cervical disease in sexually active Japanese women.
Risk factors for HPV infection and high-grade cervical disease in sexually active Japanese women.
复制标题
性活跃的日本女性中HPV感染和高级宫颈疾病的危险因素。
DOI：
10.1038/s41598-021-82354-6
复制
发表时间：
2021-02-03
影响因子：
4.6
通讯作者：
Enomoto T
中科院分区：
文献类型：
--
作者：
Yamaguchi M;Sekine M;Hanley SJB;Kudo R;Hara M;Adachi S;Ueda Y;Miyagi E;Enomoto T
在日本，由于毫无根据的安全担忧，HPV 疫苗的推荐已于 2013 年暂停。尽管疫苗反对者声称改变性行为可以预防宫颈癌，但目前还没有关于日本人群性行为和重度宫颈疾病风险的全面数据。本研究调查了 2014 年 4 月至 2016 年 3 月期间接受宫颈筛查的 3968 名 20-41 岁女性的性行为以及 HPV 感染和宫颈疾病的风险。第一次性行为的平均年龄为 18.4 岁±2.8 岁，32% 的女性报告有 ≥6 个终生性伴侣。在回归分析中，性伴侣数量是 HPV 感染的重要危险因素。然而，对于重度疾病（CIN2+），当调整 HPV 基因型时，伴侣数量没有统计学意义。最大的危险因素是 HPV16/18 感染（调整后的比值比 113.7，95% CI：40.8–316.9）。总之，我们发现 HPV16/18 感染而非性行为是年轻日本女性患高度宫颈疾病的最重要危险因素。这些感染可以通过高效疫苗来预防，我们建议日本政府立即恢复对 HPV 疫苗的主动推荐。
In Japan, recommendations for HPV vaccines were suspended in 2013 due to unfounded safety fears. Although vaccine opponents claim modifying sexual behavior can prevent cervical cancer, no comprehensive data exist on sexual behavior and the risk of high-grade cervical disease in a Japanese population. This study investigates sexual behavior and the risk of HPV infection and cervical disease in 3968 women aged 20–41 yrs undergoing cervical screening between April 2014 and March 2016. Mean age at first intercourse was 18.4 yrs ± 2.8 and 32% of women reported ≥ 6 lifetime sexual partners. In regression analyses, number of partners was a significant risk factor for HPV infection. However, for high-grade disease (CIN2+), when HPV genotype was adjusted for, number of partners was not statistically significant. The greatest risk factor was an HPV16/18 infection (adjusted odds ratio 113.7, 95% CI: 40.8–316.9). In conclusion, we found that having an HPV16/18 infection and not sexual behavior was the most significant risk factor for high grade cervical disease in young Japanese women. These infections can be prevented by a highly effective vaccine and we recommend that the Japanese government resume proactive recommendations for the HPV vaccine immediately.
登录
查看更多内容
影响因子：
6.4
作者：
Hosaka，Masayoshi;Fujita，Hiromasa;Sakuragi，Noriaki
通讯作者：
Sakuragi，Noriaki
影响因子：
50
作者：
Simms, Kate T.;Hanley, Sharon J. B.;Canfell, Karen
通讯作者：
Canfell, Karen
影响因子：
6.4
作者：
Muñoz, N;Bosch, FX;Meijer, CJLM
通讯作者：
Meijer, CJLM
影响因子：
6.4
作者：
Kudo, Risa;Yamaguchi, Manako;Enomoto, Takayuki
通讯作者：
Enomoto, Takayuki
影响因子：
6.4
作者：
Schmeink, C. E.;Massuger, L. F. A. G.;Bekkers, R. L. M.
通讯作者：
Bekkers, R. L. M.