Synergistic effect of antiangiogenic nanotherapy combined with methotrexate in the treatment of experimental inflammatory arthritis.
Synergistic effect of antiangiogenic nanotherapy combined with methotrexate in the treatment of experimental inflammatory arthritis.
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DOI：
10.2217/nnm.10.78
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发表时间：
2010-09
期刊：
影响因子：
--
通讯作者：
Pham CT
中科院分区：
文献类型：
--
作者：
Zhou HF;Hu G;Wickline SA;Lanza GM;Pham CT
本研究探讨了将αvβ3靶向夫马洁林纳米颗粒的抗血管生成作用与传统抗风湿药物甲氨蝶呤相结合来治疗炎症性关节炎的效果。通过 K/BxN 血清转移在小鼠中诱导关节炎，并通过临床评分和踝关节厚度的变化监测疾病活动。几组小鼠接受纳米颗粒或甲氨蝶呤作为单一治疗，或接受纳米颗粒和甲氨蝶呤作为联合治疗。我们发现，与单独使用任何一种药物治疗的动物相比，用脉冲剂量的夫马洁林纳米颗粒随后使用甲氨蝶呤治疗的动物具有显着改善和持续的临床反应。组织学分析证实联合治疗显着减少了炎症细胞流入、骨质侵蚀、软骨损伤和血管生成。血浆细胞因子水平的分析表明夫马洁林纳米颗粒增强了甲氨蝶呤的全身抗炎作用。当与传统的抗风湿药物联合使用时，抗血管生成纳米疗法可能是治疗炎症性关节炎的一种有前途的方法。
This study examines the effect of combining the antiangiogenic effect of αvβ3-targeted fumagillin nanoparticles with the conventional antirheumatic drug methotrexate for the treatment of inflammatory arthritis. Arthritis was induced in mice by K/BxN serum transfer, and disease activity was monitored by clinical score and change in ankle thickness. Groups of mice received nanoparticles or methotrexate as single therapy or nanoparticles and methotrexate as combination therapy. We found that animals treated with a pulse dose of fumagillin nanoparticles followed by methotrexate had significantly improved and sustained clinical response compared with those treated with either agent alone. Histological analysis confirmed a significant decrease in inflammatory cell influx, bone erosions, cartilage damage and angiogenesis with the combination therapy. Analysis of plasma cytokine levels suggests that fumagillin nanoparticles enhanced the systemic anti-inflammatory effects of methotrexate. Antiangiogenic nanotherapy may represent a promising approach for the treatment of inflammatory arthritis when combined with a conventional antirheumatic drug.
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影响因子：
4.2
作者：
Szekanecz, Zoltan;Besenyei, Timea;Paragh, Gyoergy;Koch, Alisa E.
通讯作者：
Koch, Alisa E.
影响因子：
33.7
作者：
Chan, Edwin S. L.;Cronstein, Bruce N.
通讯作者：
Cronstein, Bruce N.
影响因子：
37.8
作者：
Moulton, KS;Heller, E;Folkman, J
通讯作者：
Folkman, J
影响因子：
45.3
作者：
Herbst, RS;Madden, TL;Hong, WK
通讯作者：
Hong, WK
影响因子：
4.8
作者：
Brdlik, CM;Crews, CM
通讯作者：
Crews, CM