New insights in synovial angiogenesis.
New insights in synovial angiogenesis.
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DOI：
10.1016/j.jbspin.2009.05.011
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发表时间：
2010-01
期刊：
影响因子：
4.2
通讯作者：
Koch, Alisa E.
中科院分区：
文献类型：
--
作者：
Szekanecz, Zoltan;Besenyei, Timea;Paragh, Gyoergy;Koch, Alisa E.
血管生成是指从原有的血管中形成新的毛细血管。一些可溶的和细胞结合的因子可以刺激新生血管。涉及大量可溶性和细胞表面结合介质的血管生成的持续存在与类风湿关节炎(RA)有关。这些血管生成介质包括生长因子，主要是血管内皮生长因子(VEGF)和低氧诱导因子(HIF)，以及促炎细胞因子、各种趋化因子、细胞黏附分子、蛋白酶等。针对血管内皮生长因子、低氧诱导因子-1、血管生成素和αVβ3整合素，以及血管抑素、内皮抑素、紫杉醇、伏马西林类似物、2-甲氧基雌二醇和沙利度胺等内源性或人工合成的化合物，在防治滑膜炎症和血管生成方面具有广阔的应用前景。用于关节炎或人类类风湿性关节炎动物模型的抗血管生成药物的完整综述可在表格中找到。
Angiogenesis is the formation of new capillaries from pre-existing vessels. A number of soluble and cell-bound factors may stimulate neovascularization. The perpetuation of angiogenesis involving numerous soluble and cell surface-bound mediators has been associated with rheumatoid arthritis (RA). These angiogenic mediators, among others, include growth factors, primarily vascular endothelial growth factor (VEGF) and hypoxia-inducible factors (HIFs), as well as pro-inflammatory cytokines, various chemokines, cell adhesion molecules, proteases and others. Among the several potential angiogenesis inhibitors, targeting of VEGF, HIF-1, angiopoietin and the αVβ3 integrin, as well as some endogenous or synthetic compounds including angiostatin, endostatin, paclitaxel, fumagillin analogues, 2-methoxyestradiol and thalidomide seems to be promising for the management of synovial inflammation and angiogenesis. A complete review of antiangiogenic drugs used in animal models of arthritis or human RA is available in a table.
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影响因子：
--
作者：
Haas, Christian S.;Amin, M. Asif;Koch, Alisa E.
通讯作者：
Koch, Alisa E.
影响因子：
4.9
作者：
Giatromanolaki, A;Sivridis, E;Koukourakis, MI
通讯作者：
Koukourakis, MI
影响因子：
56.9
作者：
BROOKS, PC;CLARK, RAF;CHERESH, DA
通讯作者：
CHERESH, DA
影响因子：
4.9
作者：
Jacq, Laurent;Garnier, Sophie;Dieude, Philippe;Michou, Laetitia;Pierlot, Celine;Migliorini, Paola;Balsa, Alejandro;Westhovens, Rene;Barrera, Pilar;Alves, Helena;Vaz, Carlos;Fernandes, Manuela;Pascual-Salcedo, Dora;Bombardieri, Stefano;Dequeker, Jan;Radstake, Timothy R;Van Riel, Piet;van de Putte, Leo;Lopes-Vaz, Antonio;Glikmans, Elodie;Barbet, Sandra;Lasbleiz, Sandra;Lemaire, Isabelle;Quillet, Patrick;Hilliquin, Pascal;Teixeira, Vitor Hugo;Petit-Teixeira, Elisabeth;Mbarek, Hamdi;Prum, Bernard;Bardin, Thomas;Cornelis, Francois
通讯作者：
Cornelis, Francois
影响因子：
4.9
作者：
Goedkoop AY;Kraan MC;Picavet DI;de Rie MA;Teunissen MB;Bos JD;Tak PP
通讯作者：
Tak PP