Interleukin-6: Important Mediator of Vasospasm Following Subarachnoid Hemorrhage.
Interleukin-6: Important Mediator of Vasospasm Following Subarachnoid Hemorrhage.
复制标题
白细胞介素-6：蛛网膜下腔出血后血管痉挛的重要介质。
DOI：
10.2174/1567202618666211104122408
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发表时间：
2021
影响因子：
2.1
通讯作者：
Hoh, Brian
中科院分区：
文献类型：
--
作者：
Lucke-Wold, Brandon;Hosaka, Koji;Dodd, William;Motwani, Kartik;Laurent, Dimitri;Martinez, Melanie;Hoh, Brian
神经炎症与蛛网膜下腔出血后脑血管痉挛发生的相关性已在临床和临床前文献中得到充分记录。然而，这一过程发生的确切机制尚不清楚。最近的证据表明，白细胞介素-6不仅是一个重要的预后生物标志物蛛网膜下腔出血和随后的血管痉挛的发展，但也是一个不可分割的组成部分，在损伤的进展后，最初的侮辱。在这篇综述中，我们简要地强调了其他途径的调查和重点是什么已经发现的作用，白细胞介素6和脑血管痉挛后蛛网膜下腔出血。一个拟议的机制途径是突出的书面和图形格式。讨论人类相关的研究结果和初步的临床前机制研究。最后，在未来的调查部分，创新的发展和明确的描述领域，进一步科学探究的重点。这篇综述将促进这一领域的不断发现，并有助于寻求有效的血管痉挛治疗，目前存在有限的临床治疗方法。
The correlation of neuroinflammation with the development of cerebral vasospasm following subarachnoid hemorrhage has been well documented in the literature; both clinical and pre-clinical. The exact mechanisms by which this process occurs, however, are poorly elucidated. Recent evidence indicates that interleukin-6 is not only an important prognostic biomarker for subarachnoid hemorrhage and subsequent vasospasm development but also an integral component in the progression of injury following initial insult. In this review, we briefly highlight other pathways under investigation and focus heavily on what has been discovered regarding the role of interleukin 6 and cerebral vasospasm following subarachnoid hemorrhage. A proposed mechanistic pathway is highlighted in written and graphical format. A discussion regarding the human correlative findings and initial pre-clinical mechanistic studies is addressed. Finally, in the future investigation section, innovative developments and a clear description of areas warranting further scientific inquiry are emphasized. This review will catalyze continued discovery in this area of emerging significance and aid in the quest for effective vasospasm treatment where limited clinical therapeutics currently exist.
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影响因子：
7.4
作者：
Echigo R;Shimohata N;Karatsu K;Yano F;Kayasuga-Kariya Y;Fujisawa A;Ohto T;Kita Y;Nakamura M;Suzuki S;Mochizuki M;Shimizu T;Chung UI;Sasaki N
通讯作者：
Sasaki N
影响因子：
9.2
作者：
Erta M;Quintana A;Hidalgo J
通讯作者：
Hidalgo J
影响因子：
4.8
作者：
Bowman, G;Dixit, S;Cockroft, KM
通讯作者：
Cockroft, KM
DOI：
10.1055/s-0037-1604084
发表时间：
2018-03-01
影响因子：
1
作者：
Duris, Kamil;Neuman, Eduard;Smrcka, Martin
通讯作者：
Smrcka, Martin
影响因子：
8.3
作者：
Ko, Nerissa U.;Rajendran, Pam;Young, William L.
通讯作者：
Young, William L.