Interleukin-6, a major cytokine in the central nervous system.
Interleukin-6, a major cytokine in the central nervous system.
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DOI：
10.7150/ijbs.4679
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发表时间：
2012
影响因子：
9.2
通讯作者：
Hidalgo J
中科院分区：
文献类型：
--
作者：
Erta M;Quintana A;Hidalgo J
白细胞介素-6（IL-6）是大约30年前最初被鉴定为B细胞分化因子的细胞因子，能够诱导B细胞成熟为抗体产生细胞。与许多其他细胞因子一样，人们很快意识到IL-6不仅是参与免疫应答的因子，而且在包括神经系统在内的主要生理系统中具有许多关键作用。现在已知IL-6参与神经发生（影响神经元和神经胶质细胞两者），以及在正常条件下和在广泛的损伤模型之后参与成熟神经元和神经胶质细胞的反应。在许多方面，IL-6以神经营养因子样的方式起作用，并且似乎可以理解为什么它所属的细胞因子家族被称为神经生成素。它的表达在几种主要的脑部疾病中受到影响，动物模型强烈表明IL-6可能在观察到的神经病理学中发挥作用，因此它是战略治疗的明确目标。
Interleukin-6 (IL-6) is a cytokine originally identified almost 30 years ago as a B-cell differentiation factor, capable of inducing the maturation of B cells into antibody-producing cells. As with many other cytokines, it was soon realized that IL-6 was not a factor only involved in the immune response, but with many critical roles in major physiological systems including the nervous system. IL-6 is now known to participate in neurogenesis (influencing both neurons and glial cells), and in the response of mature neurons and glial cells in normal conditions and following a wide arrange of injury models. In many respects, IL-6 behaves in a neurotrophin-like fashion, and seemingly makes understandable why the cytokine family that it belongs to is known as neuropoietins. Its expression is affected in several of the main brain diseases, and animal models strongly suggest that IL-6 could have a role in the observed neuropathology and that therefore it is a clear target of strategic therapies.
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影响因子：
64.8
作者：
Bettelli, E;Carrier, YJ;Kuchroo, VK
通讯作者：
Kuchroo, VK
影响因子：
100.3
作者：
Baxter, Alan G.
通讯作者：
Baxter, Alan G.
影响因子：
16.2
作者：
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通讯作者：
BAZAN, JF
影响因子：
2.7
作者：
Butterweck, V;Prinz, S;Schwaninger, M
通讯作者：
Schwaninger, M
DOI：
10.1016/0736-5748(94)00061-7
发表时间：
1995-06-01
影响因子：
1.8
作者：
BENVENISTE, EN;TANG, LP;LAW, RM
通讯作者：
LAW, RM