Expression and prognostic values of ARID family members in breast cancer.
Expression and prognostic values of ARID family members in breast cancer.
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ARID家族成员在乳腺癌中的表达及预后价值
DOI：
10.18632/aging.202489
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发表时间：
2021-02-11
期刊：
影响因子：
--
通讯作者：
Pang D
中科院分区：
文献类型：
--
作者：
Zhang J;Hou S;You Z;Li G;Xu S;Li X;Zhang X;Lei B;Pang D
ARID家族是一个由15个成员组成的超家族，其中包含一个与富含AT的DNA元件相互作用的结构域。然而，每个ARID在乳腺癌中的表达和预后作用仍然是难以捉摸的。我们分别使用TCGA和Kaplan-Meier RT-PCR数据库评估ARID mRNA水平在乳腺癌中的表达和预后价值。在本研究中，6个成员在肿瘤组织中显著低于正常组织，而6个成员显著高于正常组织。进一步评估ARID在不同分子亚型乳腺癌中的表达，3个成员在无腔分子亚型中显著高于有腔分子亚型，6个成员显著高于有腔分子亚型。在预后价值方面，ARID 1A、ARID 2、ARID 3B、ARID 4A、ARID 5A、ARID 5 B、JARID 1A的高表达与良好的预后相关，而ARID 4 B和JARID 1B与较差的预后相关。我们进一步分析了ARID在乳腺癌不同内在亚型和临床病理特征中的预后价值。我们在乳腺癌中发现了许多有意义的ARID家族生物标志物。相关研究结果将进一步阐明ARID在乳腺癌中的作用，并为探索ARID靶向药物治疗乳腺癌提供新的思路。
The ARID family is a superfamily of 15 members containing a domain that interacts with AT-rich DNA elements. However, the expression and prognostic roles of each ARID in breast cancer are still elusive. We used the TCGA and Kaplan-Meier plotter databases to assess the expression and prognostic values of ARID mRNA levels in breast cancer respectively. In the present study, 6 members were significantly lower in tumor tissues than those in the normal tissues, while 6 members were significantly higher. Further assessment of ARID expression in breast cancer with different molecular subtypes, 3 members were significantly higher in no-luminal molecular subtype than those in the luminal molecular subtype, and 6 members were significantly higher. In regard to prognostic values, high expression of ARID1A, ARID2, ARID3B, ARID4A, ARID5A, ARID5B, JARID1A were associated with favorable outcome, while ARID4B and JARID1B were correlated to a worse outcome. We further analyzed the prognostic value of ARID in different intrinsic subtypes and clinicopathological features of breast cancer. We found many meaningful ARID family biomarkers in breast cancer. The relevant results will expound the role of ARID in breast cancer and may further provide new insight to explore the ARID-targeting reagents for treating breast cancer patients.
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