Exhaled volatile organic compounds as lung cancer biomarkers during one-lung ventilation.
Exhaled volatile organic compounds as lung cancer biomarkers during one-lung ventilation.
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单肺通气期间呼出的挥发性有机化合物作为肺癌生物标志物
DOI：
10.1038/srep07312
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发表时间：
2014-12-08
影响因子：
4.6
通讯作者：
Li E
中科院分区：
文献类型：
--
作者：
Wang C;Dong R;Wang X;Lian A;Chi C;Ke C;Guo L;Liu S;Zhao W;Xu G;Li E
In this study, single-lung ventilation was used to detect differences in the volatile organic compound (VOCs) profiles between lung tissues in healthy and affected lungs. In addition, changes that occurred after lung cancer resection in both the VOCs profiles of exhaled breath from ipsilateral and contralateral lungs and the VOCs profiles of exhaled breath and blood sample headspaces were also determined. Eighteen patients with non-small cell carcinoma were enrolled. Alveolar breath samples were taken separately from healthy and diseased lungs before and after the tumor resection. Solid phase microextraction–gas chromatography/mass spectrometry was used to assess the exhaled VOCs of the study participants. The VOCs exhibited significant differences between the contralateral and ipsilateral lungs before surgery, the contralateral and ipsilateral lungs after surgery, the ipsilateral lungs before and after surgery and the blood samples from before and after surgery; 12, 19, 12 and 5 characteristic metabolites played decisive roles in sample classification, respectively. 2,2-Dimethyldecane, tetradecane, 2,2,4,6,6-pentamethylheptane, 2,3,4-trimethyldecane, nonane, 3,4,5,6-tetramethyloctane and hexadecane may be generated from lipid peroxidation during surgery. Caprolactam and propanoic acid may be more promising exhaled breath biomarkers for lung cancer.
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使用比色法传感器阵列进行呼气呼吸分析，以鉴定和表征肺癌。
DOI：
10.1097/jto.0b013e318233d80f
发表时间：
2012-01
期刊：
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
影响因子：
--
作者：
Mazzone PJ;Wang XF;Xu Y;Mekhail T;Beukemann MC;Na J;Kemling JW;Suslick KS;Sasidhar M
通讯作者：
Sasidhar M
DOI：
10.1016/j.jchromb.2004.05.015
发表时间：
2004-09-05
影响因子：
3
作者：
Deng, CH;Zhang, XM;Li, N
通讯作者：
Li, N
影响因子：
168.9
作者：
Phillips, M;Gleeson, K;McVay, WP
通讯作者：
McVay, WP
影响因子：
24.3
作者：
Kischkel, Sabine;Miekisch, Wolfram;Schubert, Jochen K.
通讯作者：
Schubert, Jochen K.
DOI：
10.1016/j.nano.2011.10.001
发表时间：
2012-07
期刊：
Nanomedicine : nanotechnology, biology, and medicine
影响因子：
--
作者：
Barash O;Peled N;Tisch U;Bunn PA Jr;Hirsch FR;Haick H
通讯作者：
Haick H