Inhibition of platelet aggregation in whole blood after exposure of rats to alcohol by inhalation.
Inhibition of platelet aggregation in whole blood after exposure of rats to alcohol by inhalation.
复制标题
大鼠吸入酒精后全血中血小板聚集的抑制。
DOI：
10.1016/s0741-8329(96)00105-x
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Myers,AK
中科院分区：
文献类型：
--
作者：
Dong,QS;Karanian,JW;Wesely,L;Myers,AK
采用体外全血血小板聚集阻抗法，研究了吸入性酒精暴露大鼠全血中血液酒精浓度（BAC）与血小板功能改变之间的剂量效应关系。当室内空气中酒精的添加速率为29至56 mg乙醇/l空气/min时，BAC取决于暴露时间和空气中酒精的浓度。接下来，使用最高递送率暴露3、6和9小时，并测试血小板聚集性。9h后，BAC达到453±16 mg%，三剂量胶原蛋白的聚集反应均显著低于对照组（p < 0.01）。花生四烯酸和ADP的抑制效果不太一致，暴露时间缩短时也是如此。然而，当BAC低至127±15 mg%时，对胶原诱导的聚集有明显的抑制作用（p < 0.05）。这些实验表明，体内酒精暴露以浓度依赖的方式抑制体外大鼠全血血小板聚集，而在人体中很容易通过摄入达到bac。
The dose-effect relationship between blood alcohol concentration (BAC) and altered platelet function was examined in whole blood in a rat model of alcohol exposure by inhalation, using the impedance method of ex vivo whole blood platelet aggregation. With rates of alcohol addition to the chamber air inflow from 29 to 56 mg ethanol/l air/min, BAC was dependent on duration of exposure and concentration of alcohol in the air. Next, 3, 6, and 9 h exposures to the highest delivery rate were used, and platelet aggregability was tested. After 9h, BAC reached 453 ± 16 mg% and aggregation responses to three doses of collagen were significantly lower than in control blood (p < 0.01). Less consistent inhibition was observed with arachidonic acid and ADP, and also when exposure duration was reduced. However, some significant inhibition of collagen-induced aggregation (p < 0.05) was observed with BAC as low as 127 ± 15 mg%. These experiments demonstrate that in vivo alcohol exposure inhibits, in a concentration-dependent manner, ex vivo rat whole blood platelet aggregation, at BACs readily attained in humans by ingestion.
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乙醇抑制兔血小板凝血酶诱导的肌醇三磷酸的产生。
影响因子：
4.1
作者：
M. Rand;J. Vickers;R. Kinlough;M. Packham;J. Mustard
通讯作者：
J. Mustard
摄入乙醇会抑制人全血血小板阻抗聚集。
影响因子：
3.5
作者：
D. Mikhailidis;M. Barradas;Ola Epemolu;P. Dandona
通讯作者：
P. Dandona
乙醇对血小板的影响。
DOI：
--
发表时间：
1990
期刊：
Laboratory investigation; a journal of technical methods and pathology
影响因子：
--
作者：
R. Rubin
通讯作者：
R. Rubin
影响因子：
5
作者：
CRIQUI, MH;COWAN, LD;COHN, R
通讯作者：
COHN, R
酒精诱导的人血小板磷脂酶 C 的刺激需要 G 蛋白激活。
DOI：
10.1042/bj2540147
发表时间：
1988
期刊：
The Biochemical journal
影响因子：
--
作者：
Rubin,R;Hoek,JB
通讯作者：
Hoek,JB